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2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoate

  CAS No.: 107348-47-0   Cat No.: BADC-00486   Purity: ≥98% 4.5  

2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoate is a pyridyl disulfide-based ADC linker with NHS ester functionality, facilitating stable antibody-payload conjugation and controlled intracellular payload release to enhance ADC specificity and efficacy.

2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoate

Structure of 107348-47-0

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Category
ADC Linker
Molecular Formula
C13H14N2O4S2
Molecular Weight
326.39
Shipping
Room temperature

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
(2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)butanoate
IUPAC Name
Canonical SMILES
CC(CC(=O)ON1C(=O)CCC1=O)SSC2=CC=CC=N2
InChI
InChI=1S/C13H14N2O4S2/c1-9(20-21-10-4-2-3-7-14-10)8-13(18)19-15-11(16)5-6-12(15)17/h2-4,7,9H,5-6,8H2,1H3
InChIKey
VQZYZXLBKBUOHE-UHFFFAOYSA-N
Density
1.43g/cm3
Flash Point
237.3°C
Index Of Refraction
1.634
PSA
131.35000
Vapor Pressure
5.81E-09mmHg at 25°C
Appearance
Soild powder
Shipping
Room temperature
Boiling Point
468.8°C at 760mmHg

2,5-Dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoate is a versatile compound with significant potential in biochemical research and industrial applications. Here are some key applications of this compound:

Organic Synthesis: The compound can be used as a reagent in organic synthesis, particularly for the formation of disulfide bonds. It facilitates the introduction of sulfur atoms into molecular frameworks, making it invaluable for constructing sulfur-containing heterocycles. This is crucial for developing novel pharmaceuticals and materials with sulfur functionalities.

Bioconjugation: In the realm of biochemistry, 2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoate is employed in bioconjugation reactions where it acts as a linker between biomolecules. It is particularly effective for attaching a wide range of tags or labels to proteins and peptides. This capability is essential for applications in protein tracking, imaging, and therapeutic delivery.

Redox Research: This compound can serve as a redox agent in biochemical experiments aimed at studying oxidative stress and redox regulatory mechanisms. Its disulfide bonds can participate in redox cycling, thus allowing the investigation of cellular responses to oxidative conditions. Understanding these mechanisms helps in developing antioxidant therapies and redox-based diagnostic tools.

Drug Delivery Systems: Researchers can utilize this compound in designing sophisticated drug delivery systems. Its disulfide linkage allows for the creation of redox-responsive carriers that release payloads in environments with specific redox conditions. This targeted release approach enhances the efficacy and reduces the side effects of therapeutics, making it a promising strategy in precision medicine.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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