webinar
Oct. 27-28, 2025, Boston, MA, USA - Booth 114.
Read More

6-(Boc-amino)hexyl bromide

  CAS No.: 142356-33-0   Cat No.: BADC-00595   Purity: 98 % 4.5  

6-(Boc-amino)hexyl bromide is a Boc-protected alkyl linker used in ADC synthesis to introduce hydrophobic spacers. Its bromide group facilitates nucleophilic substitution, allowing for tailored payload conjugation and modulation of linker stability and drug release kinetics.

6-(Boc-amino)hexyl bromide

Structure of 142356-33-0

Quality
Assurance

Worldwide
Delivery

24/7 Customer
Support
Category
ADC Linker
Molecular Formula
C11H22BrNO2
Molecular Weight
280.20
Shipping
Room temperature, or blue ice upon request.
Storage
2-8 °C

* For research and manufacturing use only. We do not sell to patients.

Size Price Stock Quantity
-- $-- In stock

Looking for different specifications? Click to request a custom quote!

Capabilities & Facilities

Popular Publications Citing BOC Sciences Products
Synonyms
tert-butyl N-(6-bromohexyl)carbamate
IUPAC Name
tert-butyl N-(6-bromohexyl)carbamate
Canonical SMILES
CC(C)(C)OC(=O)NCCCCCCBr
InChI
InChI=1S/C11H22BrNO2/c1-11(2,3)15-10(14)13-9-7-5-4-6-8-12/h4-9H2,1-3H3,(H,13,14)
InChIKey
NXQXVXILNVTMNA-UHFFFAOYSA-N
Density
1.189 g/cm<sup>3</sup>
Appearance
Colourless liquid
Shipping
Room temperature, or blue ice upon request.
Storage
2-8 °C
Signal Word
Danger
Boiling Point
340.1 °C at 760 mmHg

6-(Boc-amino)hexyl bromide, a versatile molecule in organic synthesis and chemical biology, finds diverse applications across various fields. Here are four key applications presented with a high degree of perplexity and burstiness:

Peptide Synthesis: Integral to peptide synthesis, 6-(Boc-amino)hexyl bromide plays a pivotal role as a protecting group for amino functionalities. By temporarily shielding reactive amino groups, it facilitates the meticulous and controlled assembly of peptide chains in a step-wise manner. This precision is essential in yielding peptides of exceptional purity and specific sequences tailored for both research and therapeutic endeavors.

Click Chemistry: Positioned as a fundamental building block in click chemistry, this compound enables the intricate formation of complex molecules through bioorthogonal ligation. Capable of being functionalized with various azide or alkyne groups, it expedites the selective and rapid establishment of covalent bonds under mild conditions. This application proves particularly advantageous for labeling biomolecules and fostering the innovation of novel materials with unique properties.

Drug Development: In the realm of medicinal chemistry, 6-(Boc-amino)hexyl bromide finds utility in incorporating Boc-protected amino groups into pharmaceutical candidates. This modification can significantly enhance the pharmacokinetic attributes of drugs, including enhancing stability and bioavailability. Moreover, it plays a crucial role in the development of prodrugs, which are inert compounds that undergo metabolic transformation into active therapeutics within the body.

Polymer Chemistry: Employed as a key component in polymer chemistry, this compound serves as a valuable chain extender and cross-linking agent in the synthesis of functionalized polymers. By integrating Boc-amino groups into polymer structures, researchers can engineer materials with tailored physical and chemical characteristics. These specialized polymers find applications in diverse fields such as drug delivery systems, tissue engineering, and the creation of responsive hydrogels, showcasing the versatility and adaptability of this compound in polymer chemistry.

1.Synthesis of Peptidomimics Through Sugar-Based Scaffolds
Yves Le Merrer, Lydie Poitout, Jean-Claude Depezay
Poor oral bioavailability, low metabolic stability towards proteolysis and rapid excretion via both liver and kidneys displayed by innumerable peptides of potential therapeutic value has generated an intensive search for peptidomimics. A possible approach of such nonpeptidal peptidomimics is to replace the peptide by a scaffold that distributes in the space the peptidal side chains of amino acids essential for biological activity and mimics the bioactive conformation of the peptide.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Related Products

Contact our experts today for pricing and comprehensive details on our ADC offerings.

You May Also Be Interested In

From cytotoxin synthesis to linker design, discover our specialized services that complement your ADC projects.

ADC Linker Development Enzyme Cleavable Linker Cathepsin B Cleavable Linker Phosphatase Cleavable Linker β-Glucuronide Linker β-Galactosidase Cleavable Linker Sulfatase Cleavable Linker Chemically Cleavable Linker Non-Cleavable Linker Services Acid Cleavable Linker

Unlock Deeper ADC Insights

Learn more about payload design, linker strategies, and integrated CDMO support through our curated ADC content.

Linkers - A Crucial Factor in Antibody–Drug Conjugates In-Depth Review of ADC Linkers: Types, Mechanisms, and Research Progress New Structural Insights Solve Instability Issues of Maleimide Linkers in ADCs PEG Linkers in Antibody-Drug Conjugates Peptide Linkers in Antibody-Drug Conjugates Disulfide Linkers in Antibody-Drug Conjugates Biotinylation Reagents in Antibody-Drug Conjugates Maleimide Linkers in Antibody-Drug Conjugates Current ADC Linker Chemistry SPDB Linkers in Antibody-Drug Conjugates

Explore More ADC Products

Find exactly what your project needs from our expanded range of ADCs, offering flexible options to fit your timelines and goals.

ADC Cytotoxin

Powerful Targeted Cancer Solutions

ADC  Cytotoxin with Linker

Enhanced Stability And Efficacy

ADC Linker

Precise Conjugation For Success

Antibody-Drug  Conjugates (ADCs)

Maximized Therapeutic Performance

Auristatins

Next-Level Tubulin Inhibition

Calicheamicins

High-Impact DNA Targeting

Camptothecins

Advanced Topoisomerase Inhibition

Daunorubicins / Doxorubicins

Trusted Anthracycline Payloads

Duocarmycins

Potent DNA Alkylation Agents

Maytansinoids

Superior Microtubule Disruption

Pyrrolobenzodiazepines

Ultra-Potent DNA Crosslinkers

Traditional Cytotoxic Agents

Proven Chemotherapy Solutions

Cleavable Linker

Precise Intracellular Drug Release

Non-Cleavable Linker

Exceptional Long-Term Stability

Historical Records: 4-Formyl-N-(2-(o-Tolyloxy)ethyl)benzamide | N-(35-amino-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)-4-formylbenzamide | N-[gamma-Maleimidobutyryloxy]sulfo-succinimide ester | Maleimide-NH-PEG4-CH2CH2COOPFP Ester | Apaziquone | Bis-PEG4-NHS ester | Distamycin A | t-boc-N-amido-PEG4-NHS ester | 5-Maleimidovalericacid-NHS | Bromoacetamido-PEG4-NHS ester | 6-(Boc-amino)hexyl bromide
Send Inquiry
Verification code
Inquiry Basket