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Sulfo-SIAB sodium is a functionalized bioconjugation and crosslinking reagent designed to connect molecules through complementary reactive groups. Its structure provides a chemically addressable handle for covalent modification of proteins, peptides, or other functionalized substrates, with the exact coupling pathway determined by the reactive groups present in the molecule. This type of reagent is useful when a controlled spacer and orthogonal coupling chemistry are needed in a multistep conjugation workflow. Reaction stoichiometry, buffer composition, pH, competing nucleophiles, and hydrolytic stability should be considered when optimizing the coupling sequence.
Structure of 144650-93-1
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