Name: Fmoc-GGFG-Glycolic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

Fmoc-Gly-Gly-L-Phe-N-[(carboxymethoxy)methyl]Glycinamide; (S)-11-Benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid

IUPAC Name

2-[[[2-[[(2S)-2-[[2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]methoxy]acetic acid

Canonical SMILES

C1=CC=C(C=C1)CC(C(=O)NCC(=O)NCOCC(=O)O)NC(=O)CNC(=O)CNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

InChI

InChI=1S/C33H35N5O9/c39-28(16-36-33(45)47-18-26-24-12-6-4-10-22(24)23-11-5-7-13-25(23)26)34-17-30(41)38-27(14-21-8-2-1-3-9-21)32(44)35-15-29(40)37-20-46-19-31(42)43/h1-13,26-27H,14-20H2,(H,34,39)(H,35,44)(H,36,45)(H,37,40)(H,38,41)(H,42,43)/t27-/m0/s1

InChIKey

JOZGCSZISBFCOO-MHZLTWQESA-N

Appearance

White Solid

Fmoc-GGFG-Glycolic acid, a renowned peptide conjugate, finds widespread application in peptide synthesis and bioconjugation. Discover four key applications of Fmoc-GGFG-Glycolic acid:

Peptide Synthesis: Serving as a versatile building block in solid-phase peptide synthesis, Fmoc-GGFG-Glycolic acid enables the construction of intricate peptide structures. With its Fmoc protection strategy, it facilitates the methodical assembly of peptides by thwarting premature reactions, empowering researchers to synthesize peptides for diverse therapeutic, diagnostic, and research purposes.

Drug Delivery Systems: Fmoc-GGFG-Glycolic acid contributes to the design of innovative drug delivery systems encompassing peptide-drug conjugates and nanoparticles. By integrating glycolic acid, this compound enhances the solubility and stability of peptide-based therapeutics, thereby improving drug bioavailability and controlled release. Its utility in targeted drug delivery applications underscores its significance in pharmaceutical advancements.

Biomaterials Development: At the forefront of biomaterials innovation, Fmoc-GGFG-Glycolic acid plays a crucial role in the creation of hydrogels and scaffolds for tissue engineering. Through its capacity to cross-link peptide chains, it imparts structural integrity and functional attributes to biomaterials, fostering the development of bioactive materials conducive to cell growth and tissue regeneration.

Protein Interaction Studies: Leveraging Fmoc-GGFG-Glycolic acid, researchers delve into protein-peptide interactions and the formulation of peptidomimetics. By integrating this conjugate into peptides, scientists investigate binding affinities and action mechanisms of peptides with their target proteins, essential for designing peptide-based inhibitors and therapeutics aimed at precise molecular interventions.