Fmoc-Val-Ala-PAB-PNP - CAS 1394238-92-6

Fmoc-Val-Ala-PAB-PNP - CAS 1394238-92-6 Catalog number: BADC-00943

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Category
ADCs Linker
Product Name
Fmoc-Val-Ala-PAB-PNP
CAS
1394238-92-6
Catalog Number
BADC-00943
Molecular Formula
C37H36N4O9
Molecular Weight
680.70
Purity
>98.0%

Ordering Information

Catalog Number Size Price Quantity
BADC-00943 -- $-- Inquiry
Synonyms
(9H-Fluoren-9-yl)methyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate; [4-[[(2S)-2-[[(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
Canonical SMILES
CC(C)C(C(=O)NC(C)C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35
InChI
InChI=1S/C37H36N4O9/c1-22(2)33(40-36(44)48-21-32-30-10-6-4-8-28(30)29-9-5-7-11-31(29)32)35(43)38-23(3)34(42)39-25-14-12-24(13-15-25)20-49-37(45)50-27-18-16-26(17-19-27)41(46)47/h4-19,22-23,32-33H,20-21H2,1-3H3,(H,38,43)(H,39,42)(H,40,44)/t23-,33-/m0/s1
InChIKey
ZJHZWBDLYYJQAV-WYOOIXGGSA-N
Solubility
10 mm in DMSO
Shelf Life
≥ 2 years
Shipping
Room temperature
Storage
Store at -20 °C, keep in dry and avoid sunlight.

Fmoc-Val-Ala-PAB-PNP is a compound used primarily in biochemical and pharmaceutical research, specifically in peptide synthesis and as a linker in drug delivery systems. Here are some key applications of Fmoc-Val-Ala-PAB-PNP:

Peptide Synthesis: Fmoc-Val-Ala-PAB-PNP is employed in the solid-phase synthesis of peptides, providing a reliable building block for creating longer peptide chains. Its Fmoc protective group ensures stability during synthesis and can be easily removed under mild conditions. This makes it an essential reagent for generating high-purity peptides for research and therapeutic applications.

Targeted Drug Delivery: Fmoc-Val-Ala-PAB-PNP serves as a linker molecule in the development of prodrugs and targeted drug delivery systems. By attaching therapeutic agents to this linker, drugs can be released selectively in target tissues or cells, improving efficacy and reducing side effects. This approach is particularly useful in cancer therapy, where precise drug delivery is crucial.

Enzyme Probes: Researchers use Fmoc-Val-Ala-PAB-PNP as a substrate for enzyme activity studies. The compound can be designed to release a detectable signal upon enzymatic cleavage, allowing scientists to monitor specific enzyme activities in vitro and in vivo. This application is essential for understanding enzyme function and for screening potential enzyme inhibitors.

Bioconjugation: Fmoc-Val-Ala-PAB-PNP is used in bioconjugation techniques to attach peptides or other biomolecules to a variety of surfaces or carriers. This makes it possible to create peptide-functionalized biomaterials and biosensors. Such advancements facilitate the study of protein-protein interactions and the development of diagnostic tools.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Fmoc-Val-Ala-PAB-PNP
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