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MP-Ala-Ala-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01693 | -- | $-- | Inquiry |
MP-Ala-Ala-PAB, a pivotal chemical compound in protease-activated systems, boasts diverse applications ranging from drug delivery to diagnostics.
Drug Delivery Systems: By leveraging MP-Ala-Ala-PAB as a prodrug linker, researchers enable the precise release of active pharmaceutical ingredients upon cleavage by specific proteases within the target environment, such as tumor tissues. This targeted drug delivery strategy not only minimizes systemic side effects but also enhances therapeutic efficacy.
Diagnostic Imaging: Integrated into imaging probes, MP-Ala-Ala-PAB initiates activation upon encountering specific proteases, enabling real-time visualization of enzymatic activity in vivo. This dynamic capability aids in diagnosing diseases characterized by abnormal protease activity, such as cancer and inflammatory conditions.
Enzyme Activity Assays: Within research domains, MP-Ala-Ala-PAB serves as a cornerstone in developing substrate-based assays to measure protease activity in biological specimens. These assays play a crucial role in unraveling the roles of proteases in various physiological and pathological processes. By exploring enzyme kinetics and inhibition pathways, researchers contribute to drug discovery efforts and the identification of novel biomarkers to advance precision medicine.
Therapeutic Research: Through the design of inhibitors or activators that interact with MP-Ala-Ala-PAB linkers, scientists aim to regulate protease functions implicated in diseases like cancer and Alzheimer's. This targeted therapeutic approach not only enhances specificity but also mitigates off-target effects.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
