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Biotin-PEG4-OH

  CAS No.: 1778736-18-7   Cat No.: BADC-01552   Purity: 95% 4.5  

Biotin-PEG4-OH is a polyethylene glycol (PEG)-based PROTAC linker. Biotin-PEG4-OH can be used in the synthesis of a series of PROTACs.

Biotin-PEG4-OH

Structure of 1778736-18-7

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Category
ADC Linker
Molecular Formula
C18H33N3O6S
Molecular Weight
419.54

* For research and manufacturing use only. We do not sell to patients.

Size Price Stock Quantity
500 mg $599 In stock

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Capabilities & Facilities

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Synonyms
Biotin-PEG4-alcohol; N-(2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
IUPAC Name
5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]pentanamide
Canonical SMILES
C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)NCCOCCOCCOCCO)NC(=O)N2
InChI
InChI=1S/C18H33N3O6S/c22-6-8-26-10-12-27-11-9-25-7-5-19-16(23)4-2-1-3-15-17-14(13-28-15)20-18(24)21-17/h14-15,17,22H,1-13H2,(H,19,23)(H2,20,21,24)/t14-,15-,17-/m0/s1
InChIKey
ZXIIDTTUJDVFCP-ZOBUZTSGSA-N
Density
1.189±0.06 g/cm3 (Predicted)
Solubility
Moderately soluble
Appearance
White Solid
Pictograms
Harmful
Signal Word
Warning
Boiling Point
718.6±60.0 °C (Predicted)

Pharmaceutical and Therapeutic Applications: N-(2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide shows significant promise in the pharmaceutical industry, particularly for its potential as a therapeutic agent in treating complex diseases. The compound’s structure includes both a thienoimidazole ring system and a pentanamide side chain, which may interact with various biological targets, such as enzymes or receptors involved in disease progression. Researchers have explored its potential in the development of anti-cancer therapies, as its chemical composition suggests it could affect cellular mechanisms like apoptosis and cell proliferation. Additionally, its ability to modulate immune responses makes it a candidate for autoimmune disease treatment. The compound’s unique functional groups also contribute to its pharmacokinetic properties, enhancing its bioavailability and therapeutic efficacy.

Drug Delivery Systems: The complex structure of N-(2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide makes it an ideal candidate for drug delivery applications. The compound can serve as a component in advanced drug delivery systems, such as liposomes or nanoparticles. Its hydrophilic (due to the ethoxy groups) and lipophilic (due to the thienoimidazole ring) properties enable it to be functionalized for targeted delivery. This dual characteristic allows the compound to enhance the stability and controlled release of therapeutic agents, reducing side effects and improving the efficacy of the drugs. This feature is especially useful in delivering drugs to specific tissues or organs, such as in cancer or neurological treatments.

Biomolecular Probing and Diagnostic Applications: In addition to its pharmaceutical potential, this compound has utility in chemical biology and diagnostic applications. Due to its unique molecular structure, it can be used as a probe to study specific biomolecular interactions. By functionalizing it with fluorescent or other detectable tags, it could serve as a diagnostic tool for identifying biomarker expression in diseases such as cancer or neurodegenerative disorders. Furthermore, the compound could be employed in assays to evaluate the efficacy of novel drugs or therapeutic interventions, facilitating the development of personalized medicine strategies.

Material Science and Nanotechnology: N-(2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide’s unique chemical and structural characteristics extend its applications to materials science and nanotechnology. The compound’s ethoxy groups provide opportunities for functionalizing surfaces and creating self-assembled monolayers, which are useful in nanostructure design and nanosensing devices. Additionally, its thienoimidazole core enables it to participate in electronic or catalytic processes, offering potential applications in developing new materials for sensors, batteries, or catalysts. These properties make it an attractive candidate for innovation in the development of advanced materials in both industrial and scientific settings.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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