CAS No.: 202284-84-2
Purity: ≥95%
HNMR
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Solid Chemical phosphorylation reagent II is a click chemistry reagent for the synthesis of oligonucleotides possessing 5'-terminal phosphate residues.
Structure of 202284-84-2
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| Size | Price | Stock | Quantity |
|---|---|---|---|
| 250 mg | $299 | In stock |
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Solid Chemical Phosphorylation Reagent II is a specialized ADC linker reagent designed to facilitate the development of antibody-drug conjugates (ADCs) and other bioconjugation applications. As a phosphorylation-based linker reagent, it enables precise chemical modification of monoclonal antibodies and related biomolecules, allowing stable attachment of ADC cytotoxins or functional payloads. Its solid-phase format supports controlled reactions and improved reproducibility, which is essential in modern ADC linker design. By using Solid Chemical Phosphorylation Reagent II, researchers can achieve site-specific conjugation while maintaining antibody integrity, ensuring optimal pharmacokinetics and therapeutic efficacy in targeted drug delivery systems.
In ADC cytotoxin conjugation, Solid Chemical Phosphorylation Reagent II offers versatility for linking various payloads, including microtubule inhibitors, DNA-intercalating agents, and other potent cytotoxins. Its phosphorylation chemistry provides stable bonds that can withstand physiological conditions yet allow controlled release of payloads in the intracellular environment of target tumor cells. The solid-phase nature of the reagent facilitates handling and scalability, making it suitable for both preclinical research and industrial ADC production. This chemical strategy enhances modular ADC linker design, supporting efficient bioconjugation and reproducible construction of ADC payload conjugates.
From an application perspective, Solid Chemical Phosphorylation Reagent II is extensively used in oncology-focused ADC research, protein modification studies, and advanced drug delivery systems. Its predictable reactivity and compatibility with diverse ADC cytotoxins enable precise design of antibody-linker-payload constructs, improving tumor specificity and intracellular payload release. Researchers can leverage this reagent to develop robust ADC linker strategies that maintain antibody function, optimize pharmacokinetics, and minimize off-target effects. Its chemical versatility and solid-phase format make it an essential tool for modern ADC linker design and targeted therapy development.
What is Solid Chemical phosphorylation reagent II used for in ADC synthesis?
Solid Chemical phosphorylation reagent II is used for introducing phosphate groups to hydroxyl-containing molecules, allowing subsequent conjugation steps in ADC synthesis. It provides a stable and reactive intermediate for linker functionalization and payload attachment.
8/12/2019
Dear BOC Sciences, could you explain how Solid Chemical phosphorylation reagent II enhances ADC linker functionality?
The reagent phosphorylates hydroxyl groups, creating reactive phosphate esters that can participate in further chemical reactions, enabling stable attachment of payloads and enhancing solubility and stability of ADCs.
20/9/2018
Dear BOC Sciences, which payloads are compatible with linkers modified using Solid Chemical Phosphorylation Reagent II?
It can be used with hydroxyl-containing cytotoxins, peptides, or other small molecules. Phosphate modification facilitates conjugation to amine- or thiol-containing antibodies while maintaining ADC structural integrity.
2/2/2019
Dear team, what are the recommended reaction conditions for using this reagent?
Phosphorylation is performed under anhydrous or controlled aqueous conditions, often with mild bases, to ensure selective activation while preserving functional groups and maintaining compatibility with subsequent ADC conjugation steps.
18/9/2020
Dear team, what are the recommended storage and handling conditions for Solid Chemical phosphorylation reagent II?
Solid Chemical phosphorylation reagent II should be stored in a cool, dry environment, away from light and moisture. Handling should be performed using gloves and protective equipment. Inert gas or vacuum-sealed storage is recommended to maintain chemical stability. Supporting documentation provides detailed handling and storage guidelines.
30/2/2018
— Dr. Alexander Schmidt, Senior Chemist (Germany)
Solid Chemical phosphorylation reagent II allowed precise phosphorylation with minimal by-products.
2/2/2019
— Ms. Grace Wilson, Biochemist (UK)
Excellent batch-to-batch reproducibility made Solid Chemical phosphorylation reagent II reliable.
30/2/2018
— Dr. Ethan Parker, Medicinal Chemist (USA)
The reagent performed consistently in multi-step linker synthesis.
18/9/2020
— Dr. Camille Dubois, Senior Scientist (France)
Solid Chemical phosphorylation reagent II facilitated smooth conjugation reactions and high yields.
8/12/2019
— Dr. Matteo Rossi, Chemist (Italy)
Using this reagent allowed us to access phosphorylated linkers that were previously difficult to synthesize.
— Ms. Emma Johansson, Synthetic Chemist (Sweden)
We relied on Solid Chemical phosphorylation reagent II for our lab-scale synthesis. The reagent performed reliably, and BOC Sciences’ datasheets were highly informative.
20/9/2018
Solid Chemical phosphorylation reagent II
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Solid Chemical phosphorylation reagent II
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