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Mal-NH-PEG2-BCN is an ADC Linker containing 2 PEG units.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01743 | -- | $-- | Inquiry |
Mal-NH-PEG2-BCN, a versatile bifunctional crosslinker, finds diverse applications in bioconjugation and material sciences.
Bioconjugation: In the realm of bioconjugation, Mal-NH-PEG2-BCN plays a pivotal role in linking biomolecules like proteins or peptides using maleimide and BCN groups. This crosslinker facilitates the formation of stable conjugates through click chemistry reactions, including the strain-promoted azide-alkyne cycloaddition (SPAAC). The inclusion of a PEG2 spacer not only enhances solubility but also mitigates steric hindrance, ensuring efficient conjugation while preserving biological activity with finesse.
Targeted Drug Delivery: Delving into targeted drug delivery systems, Mal-NH-PEG2-BCN acts as the linchpin for attaching therapeutic agents to carrier molecules such as liposomes or nanoparticles. By functionalizing these carriers with targeting ligands, precise delivery to afflicted cells or tissues is achieved, boosting efficacy and minimizing adverse effects.
Hydrogel Formation: Transitioning to hydrogel formation, Mal-NH-PEG2-BCN emerges as a vital crosslinking agent in crafting hydrogels essential for various biomedical applications, from tissue engineering to drug release systems. The BCN group expedites gelation through bioorthogonal click reactions, yielding hydrogels with adjustable mechanical properties. These customizable hydrogels can emulate tissue microenvironments, fostering cell growth and differentiation in the realm of regenerative medicine with finesse.
Biosensor Development: In the landscape of biosensor development, Mal-NH-PEG2-BCN shines as the go-to choice for immobilizing sensing elements like antibodies or enzymes onto sensor surfaces. This bifunctional crosslinker ensures robust and specific attachment while preserving the biological functionality of the immobilized biomolecules. Such sensors find applications in clinical diagnostics, environmental monitoring, and food safety testing, offering sensitive and rapid detection of target analytes while upholding precision and reliability.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, non-natural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
