Name: Mal-NH-PEG2-BCN
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

BCN-exo-PEG2-maleimide

IUPAC Name

9-bicyclo[6.1.0]non-4-ynylmethyl N-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethyl]carbamate

Canonical SMILES

C1CC2C(C2COC(=O)NCCOCCOCCNC(=O)CCN3C(=O)C=CC3=O)CCC#C1

InChI

InChI=1S/C24H33N3O7/c28-21(9-12-27-22(29)7-8-23(27)30)25-10-13-32-15-16-33-14-11-26-24(31)34-17-20-18-5-3-1-2-4-6-19(18)20/h7-8,18-20H,3-6,9-17H2,(H,25,28)(H,26,31)

InChIKey

WOCRQFMPRIJWEQ-UHFFFAOYSA-N

Mal-NH-PEG2-BCN, a versatile bifunctional crosslinker, finds diverse applications in bioconjugation and material sciences.

Bioconjugation: In the realm of bioconjugation, Mal-NH-PEG2-BCN plays a pivotal role in linking biomolecules like proteins or peptides using maleimide and BCN groups. This crosslinker facilitates the formation of stable conjugates through click chemistry reactions, including the strain-promoted azide-alkyne cycloaddition (SPAAC). The inclusion of a PEG2 spacer not only enhances solubility but also mitigates steric hindrance, ensuring efficient conjugation while preserving biological activity with finesse.

Targeted Drug Delivery: Delving into targeted drug delivery systems, Mal-NH-PEG2-BCN acts as the linchpin for attaching therapeutic agents to carrier molecules such as liposomes or nanoparticles. By functionalizing these carriers with targeting ligands, precise delivery to afflicted cells or tissues is achieved, boosting efficacy and minimizing adverse effects.

Hydrogel Formation: Transitioning to hydrogel formation, Mal-NH-PEG2-BCN emerges as a vital crosslinking agent in crafting hydrogels essential for various biomedical applications, from tissue engineering to drug release systems. The BCN group expedites gelation through bioorthogonal click reactions, yielding hydrogels with adjustable mechanical properties. These customizable hydrogels can emulate tissue microenvironments, fostering cell growth and differentiation in the realm of regenerative medicine with finesse.

Biosensor Development: In the landscape of biosensor development, Mal-NH-PEG2-BCN shines as the go-to choice for immobilizing sensing elements like antibodies or enzymes onto sensor surfaces. This bifunctional crosslinker ensures robust and specific attachment while preserving the biological functionality of the immobilized biomolecules. Such sensors find applications in clinical diagnostics, environmental monitoring, and food safety testing, offering sensitive and rapid detection of target analytes while upholding precision and reliability.