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| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01041 | -- | $-- | Inquiry |
Mal-PEG2-Val-Cit-amido-PAB-OH, a chemical linker commonly utilized in the development of antibody-drug conjugates (ADCs) and other bioconjugates, has diverse applications.
1. Antibody-Drug Conjugates (ADCs): At the forefront of targeted cancer therapy, Mal-PEG2-Val-Cit-amido-PAB-OH plays a pivotal role in attaching cytotoxic drugs to antibodies, forming ADCs with remarkable precision. This linker ensures stability in the bloodstream and triggers drug release specifically inside cancer cells upon internalization. This precise targeting reduces systemic toxicity and amplifies the therapeutic efficacy of cancer treatments, showcasing the potential of precision medicine.
2. Bioconjugation: Beyond ADCs, this versatile linker finds application in various bioconjugation techniques, facilitating the attachment of biomolecules like peptides, proteins, and nucleic acids to diverse assays and therapeutic platforms. With its maleimide group enabling selective conjugation to thiol groups on proteins, this linker guarantees a robust and stable attachment, essential for the development of diagnostic tools and therapeutic agents with unparalleled specificity and performance.
3. Drug Delivery Systems: In the realm of drug delivery research, Mal-PEG2-Val-Cit-amido-PAB-OH emerges as a key player in enhancing the delivery and release dynamics of therapeutic agents. The PEGylation component not only enhances solubility and diminishes immunogenicity, but also the cleavable linker allows for controlled drug release at designated sites.
4. Chemical Biology Studies: In chemical biology, researchers leverage this linker to dissect protein-protein interactions and cellular processes. By conjugating small molecules or probes to proteins of interest, scientists can meticulously track or modulate biological functions in a precise manner. This approach serves as a powerful tool in unraveling complex biological pathways and pinpointing potential drug targets across a spectrum of diseases, underscoring the pivotal role of chemical biology in advancing therapeutic interventions.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
