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CAS No.: 2055041-38-6
Cat No.: BADC-01041
Purity: >98.0%
4.5 
Mal-PEG2-Val-Cit-amido-PAB-OH is a maleimide-activated ADC linker designed for thiol-reactive conjugation. Featuring a cathepsin B-cleavable Val-Cit-PAB motif, it ensures efficient intracellular drug release in antibody-drug conjugates targeting cancer cells.
Structure of 2055041-38-6
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Mal-PEG2-Val-Cit-amido-PAB-OH, a chemical linker commonly utilized in the development of antibody-drug conjugates (ADCs) and other bioconjugates, has diverse applications.
1. Antibody-Drug Conjugates (ADCs): At the forefront of targeted cancer therapy, Mal-PEG2-Val-Cit-amido-PAB-OH plays a pivotal role in attaching cytotoxic drugs to antibodies, forming ADCs with remarkable precision. This linker ensures stability in the bloodstream and triggers drug release specifically inside cancer cells upon internalization. This precise targeting reduces systemic toxicity and amplifies the therapeutic efficacy of cancer treatments, showcasing the potential of precision medicine.
2. Bioconjugation: Beyond ADCs, this versatile linker finds application in various bioconjugation techniques, facilitating the attachment of biomolecules like peptides, proteins, and nucleic acids to diverse assays and therapeutic platforms. With its maleimide group enabling selective conjugation to thiol groups on proteins, this linker guarantees a robust and stable attachment, essential for the development of diagnostic tools and therapeutic agents with unparalleled specificity and performance.
3. Drug Delivery Systems: In the realm of drug delivery research, Mal-PEG2-Val-Cit-amido-PAB-OH emerges as a key player in enhancing the delivery and release dynamics of therapeutic agents. The PEGylation component not only enhances solubility and diminishes immunogenicity, but also the cleavable linker allows for controlled drug release at designated sites.
4. Chemical Biology Studies: In chemical biology, researchers leverage this linker to dissect protein-protein interactions and cellular processes. By conjugating small molecules or probes to proteins of interest, scientists can meticulously track or modulate biological functions in a precise manner. This approach serves as a powerful tool in unraveling complex biological pathways and pinpointing potential drug targets across a spectrum of diseases, underscoring the pivotal role of chemical biology in advancing therapeutic interventions.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00442 | Mal-PEG6-NHS | 1137109-21-7 | |
| BADC-00448 | Mal-PEG-NHS | 1260092-50-9 | |
| BADC-00443 | Mal-PEG5-NHS | 1315355-92-0 | |
| BADC-00450 | Mal-PEG4-NHS | 1325208-25-0 | |
| BADC-01679 | Mal-PEG2-Val-Cit-PABA-PNP | 1345681-52-8 | |
| BADC-00936 | Mal-PEG2-acid | 1374666-32-6 | |
| BADC-00449 | Mal-PEG4-PFP | 1415800-42-8 | |
| BADC-00453 | Mal-PEG2-NHS ester | 1433997-01-3 | |
| BADC-00603 | Mal-PEG3-NHS ester | 1537892-36-6 | |
| BADC-00966 | Mal-PEG4-VC-PAB-DMEA | 1569261-93-3 |
What is Mal-PEG2-Val-Cit-amido-PAB-OH used for in ADC development?
Mal-PEG2-Val-Cit-amido-PAB-OH is a cleavable linker used in antibody-drug conjugates (ADCs) to connect cytotoxic payloads to antibodies. Its Val-Cit dipeptide sequence allows for selective protease-mediated cleavage in target cells, ensuring controlled release of the drug while maintaining stability in circulation.
27/2/2020
Dear team, how does the stability of Mal-PEG2-Val-Cit-amido-PAB-OH impact ADC performance?
The stability of Mal-PEG2-Val-Cit-amido-PAB-OH in plasma is critical to prevent premature drug release. Its PEG2 spacer and PAB moiety contribute to aqueous solubility and reduce aggregation, supporting consistent pharmacokinetics and minimizing off-target toxicity.
29/12/2022
Dear team, can Mal-PEG2-Val-Cit-amido-PAB-OH be customized for different payloads?
Yes, Mal-PEG2-Val-Cit-amido-PAB-OH is compatible with a range of cytotoxic agents bearing thiol groups. The maleimide functional group allows selective conjugation, and its modular design supports adjustments in linker length or PEG content to optimize ADC properties.
30/2/2018
Good morning! Could you please advise what analytical methods are recommended for Mal-PEG2-Val-Cit-amido-PAB-OH characterization?
Characterization of Mal-PEG2-Val-Cit-amido-PAB-OH typically involves HPLC for purity assessment, mass spectrometry for molecular weight confirmation, and NMR spectroscopy for structural verification, ensuring precise quality control for ADC applications.
10/9/2017
Good afternoon! Which analytical and supporting documents are available for Mal-PEG2-Val-Cit-amido-PAB-OH?
BOC Sciences provides Mal-PEG2-Val-Cit-amido-PAB-OH with a Certificate of Analysis, NMR spectra, and mass spectrometry data. These documents confirm chemical identity and structural integrity, ensuring reproducibility and reliability for research applications. Full documentation is available upon request.
12/9/2020
— Dr. Oliver Brown, Senior Scientist (UK)
Mal-PEG2-Val-Cit-amido-PAB-OH facilitated highly efficient maleimide-thiol conjugations.
30/2/2018
— Ms. Clara Weber, Biochemist (Germany)
Excellent solubility and lot consistency enabled seamless multi-step synthesis.
12/9/2020
— Dr. Ethan Parker, Medicinal Chemist (USA)
The linker performed reliably in our ADC conjugation workflows.
10/9/2017
— Dr. Sophie Moreau, Senior Scientist (France)
Minimal side reactions were observed, ensuring high yield and product quality.
27/2/2020
— Dr. Liam Fischer, Chemist (UK)
Using this linker, we explored novel drug-release mechanisms.
— Ms. Sarah Thompson, ADC Researcher (USA)
Mal-PEG2-Val-Cit-amido-PAB-OH was delivered exactly as specified. It performed reliably in our ADC linker studies, supporting reproducible results.
29/12/2022
Mal-PEG2-Val-Cit-amido-PAB-OH
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Mal-PEG2-Val-Cit-amido-PAB-OH
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