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m-PEG4-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG4-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01186 | -- | $-- | Inquiry |
m-PEG4-Boc, a versatile polyethylene glycol derivative widely utilized in chemical synthesis, boasts diverse applications in pharmaceuticals and biotechnology. Here are four key applications of m-PEG4-Boc:
Drug Delivery Systems: The integration of m-PEG4-Boc in drug conjugate synthesis involves leveraging it as a hydrophilic linker to boost the solubility and stability of therapeutic agents. Through conjugation with this polymer, optimizations in pharmacokinetic profiles are achieved, resulting in prolonged circulation times and mitigated side effects.
Peptide and Protein Modification: In the realm of pegylating peptides and proteins, m-PEG4-Boc plays a pivotal role by attaching polyethylene glycol chains to these biomolecules. Pegylation with m-PEG4-Boc serves to augment molecular weight and modify pharmacodynamics, culminating in heightened bioavailability and reduced immunogenicity of therapeutic proteins.
Surface Functionalization: Within the domain of material science, m-PEG4-Boc is harnessed to modify surfaces, rendering them biocompatible and minimizing nonspecific binding. The presence of PEG chains on surfaces acts as a deterrent to protein adsorption and cell adhesion, critical for biomedical device and diagnostic instrument development. This functionalization is paramount in ensuring the efficacy and safety of implantable devices and sensors.
Bioconjugation: A mainstay in bioconjugation reactions, m-PEG4-Boc assumes a crucial role in linking biomolecules with diverse functional entities like fluorescent probes and therapeutic agents. The compound’s stability and ease of removal position it as a preferred choice for temporary protection during chemical synthesis processes. This application plays a pivotal role in crafting advanced pharmaceuticals for therapy and imaging, demanding precise spatial and functional control for optimal outcomes.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, non-natural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
