6-Maleimidocaproic acid can be used as a spacer group to construct drugs and other types of biological conjugals. 6-maleimide hexanoic acid and N-hydroxysuccinimide were used as bifunctional cross-linking reagent. It can also be used as a probe for mercaptan group (SH-group) in membrane protein.
Catalog Number | Size | Price | Quantity |
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BADC-01624 | -- | $-- |
6-Maleimidocaproic acid is a versatile chemical compound mainly used in biochemical and biomedical applications. Here are some key applications of 6-Maleimidocaproic acid:
Protein Labeling: 6-Maleimidocaproic acid is widely used for labeling proteins with fluorescent dyes, enzymes, or other molecules. Its maleimide group reacts specifically with thiol groups on cysteine residues, forming stable thioether bonds. This allows researchers to track or quantify proteins in various biochemical assays and imaging studies.
Antibody-Drug Conjugates: In the development of antibody-drug conjugates (ADCs), 6-Maleimidocaproic acid serves as a linker molecule. It connects a potent cytotoxic drug to an antibody that targets cancer cells. This precise linkage ensures that the therapeutic payload is delivered specifically to cancer cells, minimizing side effects on healthy tissues.
Surface Modification: 6-Maleimidocaproic acid can be used to modify surfaces of biomaterials and nanomaterials with thiol-reactive groups. By functionalizing surfaces with specific proteins or ligands, it enhances their biocompatibility and specificity for biomedical applications such as biosensors, medical implants, and targeted drug delivery systems.
Peptide Synthesis: In peptide synthesis, 6-Maleimidocaproic acid is employed as a crosslinking agent to form stable peptide conjugates. By reacting with thiol groups in peptide chains, it helps in creating cyclic peptides or multidomain peptide structures. This is particularly useful in developing peptide-based therapeutics and studying protein-protein interactions.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.