DBCO-acid - CAS 1353016-70-2 Catalog number: BADC-00932

DBCO-acid, a versatile chemical reagent for click chemistry applications, facilitates bioorthogonal conjugation seamlessly within biological systems. Here are four key applications of DBCO-acid:

Bioconjugation: Widely utilized for labeling biomolecules like proteins, peptides, and nucleic acids with diverse probes and tags, DBCO-acid enables the formation of stable covalent bonds through strain-promoted azide-alkyne cycloaddition (SPAAC) reactions. This precise method allows for the creation of well-defined conjugates crucial for imaging, diagnostics, and therapeutic interventions.

Drug Delivery: Within targeted drug delivery, DBCO-acid plays a pivotal role in attaching therapeutic compounds to specific targeting moieties such as antibodies or peptides. By conjugating drugs to these molecules, it enables site-specific delivery, enhancing therapeutic efficacy while minimizing off-target effects.

Surface Functionalization: In the realm of biomaterials and nanoparticles, DBCO-acid can be harnessed for surface functionalization in various biomedical applications. By modifying surfaces with DBCO groups, researchers can anchor azide-functionalized biomolecules, creating a versatile platform for applications like biosensors, tissue engineering, and regenerative medicine. This technique ensures precise and stable attachment of functional groups to the surface, enabling tailored applications.

Molecular Probes: Playing a pivotal role in designing molecular probes for biological assays and imaging studies, DBCO-acid facilitates the conjugation of fluorescent dyes or biotin to azide-functionalized molecules via DBCO chemistry. This approach allows researchers to monitor and track biological processes in real time, essential for studying cellular mechanisms, drug interactions, and biomolecular dynamics across diverse biological systems.