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Propargyl-Tos

  CAS No.: 23418-85-1   Cat No.: BADC-01519 4.5  

Propargyl-Tos is a highly reactive propargylation reagent used in click-compatible ADC linker synthesis. Featuring a tosylate leaving group and terminal alkyne, it enables bioorthogonal conjugation via azide-alkyne cycloaddition, ensuring fast and selective functionalization in antibody-drug payload assembly.

Propargyl-Tos

Structure of 23418-85-1

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Category
ADC Linker
Molecular Formula
C11H12O3S
Molecular Weight
224.28

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Popular Publications Citing BOC Sciences Products
Synonyms
3-Butynyl p-toluenesulfonate; but-3-ynyl 4-methylbenzenesulfonate; but-3-yn-1-yl 4-methylbenzenesulfonate; 3-butynyl tosylate; 3-butynyl 4-methylbenzenesulfonate; 3-butynyl 4-toluenesulfonate; Propargyl-Tos; p-Toluenesulfonic Acid 3-Butynyl Ester
IUPAC Name
but-3-ynyl 4-methylbenzenesulfonate
Canonical SMILES
CC1=CC=C(C=C1)S(=O)(=O)OCCC#C
InChI
InChI=1S/C11H12O3S/c1-3-4-9-14-15(12,13)11-7-5-10(2)6-8-11/h1,5-8H,4,9H2,2H3
InChIKey
STOASOOVVADOKH-UHFFFAOYSA-N
Density
1.012 g/cm<sup>3</sup>
Appearance
Liquid
Pictograms
Irritant
Signal Word
Warning
Boiling Point
352 °C at 760 mmHg

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: Phe-Lys(Trt)-PAB | 3-azidopropanoate-N-hydroxysuccinimide ester | Propargyl-O-C1-amido-PEG3-C2-NHS ester | Azido-PEG1-Val-Cit-PABC-PNP | (E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate | N-succinimidyl-6-(2-pyridyldithio)capronate | N-(2-(2,4-Dimethylphenoxy)ethyl)-4-Formylbenzamide | AcLys-PABC-VC-Aur0101 intermediate-1 | Aminooxy-PEG2-bis-PEG3-BCN | 2,5-dioxopyrrolidin-1-yl 1-(cyclooct-2-ynyloxy)-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate | Propargyl-Tos
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