Inquiry Basket
CAS No.: 2093153-99-0
Cat No.: BADC-01054
Purity: >98.0%
4.5 
Propargyl-PEG6-NHS ester offers a PEG6 spacer with terminal NHS ester and alkyne group, optimized for bioorthogonal conjugation. This ADC linker improves payload solubility and precise attachment in next-generation antibody-drug conjugates.
Structure of 2093153-99-0
* For research and manufacturing use only. We do not sell to patients.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
Popular Publications Citing BOC Sciences Products
Propargyl-PEG6-NHS ester is a highly versatile ADC linker intermediate widely used in antibody-drug conjugate (ADC) construction and targeted bioconjugation studies. Featuring a hydrophilic PEG6 spacer and a reactive N-hydroxysuccinimide (NHS) ester, it enables efficient and site-specific conjugation with primary amine groups on monoclonal antibodies or ADC cytotoxins. The terminal propargyl group allows additional modular conjugation through click chemistry, supporting flexible ADC linker design. In ADC linker applications, Propargyl-PEG6-NHS ester enhances solubility, reduces aggregation, and maintains antibody functionality, enabling precise delivery of therapeutic payloads to tumor cells.
In payload conjugation applications, Propargyl-PEG6-NHS ester is compatible with a wide variety of ADC cytotoxins, including DNA-targeting agents, microtubule inhibitors, and other potent therapeutic payloads. Its PEG6 spacer improves flexibility and aqueous solubility, facilitating stable and homogeneous ADC construction. The NHS ester enables predictable, reproducible, and mild reaction conditions for efficient attachment of payloads, while the propargyl functionality provides options for secondary click chemistry modifications. Researchers can employ this linker intermediate to optimize linker length, enhance intracellular payload release, and construct high-performance ADCs suitable for both preclinical research and scalable industrial production.
From an application perspective, Propargyl-PEG6-NHS ester is extensively used in oncology-focused ADC research, targeted drug delivery studies, and protein bioconjugation experiments. Its hydrophilic PEG chain improves circulation time and reduces aggregation of ADC payloads, while the combination of NHS ester and propargyl groups ensures site-specific, flexible, and efficient conjugation. By integrating Propargyl-PEG6-NHS ester into ADC linker design, developers can construct flexible, stable, and highly soluble linker-payload constructs, enabling tumor-specific delivery and optimized pharmacokinetics in modern ADC development.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00941 | Propargyl-PEG5-NHS ester | 1393330-40-9 | |
| BADC-00430 | Propargyl-PEG4-NHS ester | 1428629-70-2 | |
| BADC-00950 | Propargyl-PEG3-NHS ester | 1428629-71-3 | |
| BADC-01053 | Propargyl-PEG7-NHS ester | 2093152-77-1 | |
| BADC-01078 | Propargyl-PEG8-NHS ester | 2182601-74-5 |
What is Propargyl-PEG6-NHS ester and its role in ADCs?
Propargyl-PEG6-NHS ester is a bifunctional linker featuring a PEG6 spacer, NHS ester for amine conjugation, and a propargyl group for click chemistry. It facilitates selective and stable attachment of payloads to antibodies.
3/9/2020
Could you advise how Propargyl-PEG6-NHS ester enables site-specific conjugation?
The NHS ester reacts efficiently with lysine residues on antibodies, while the terminal propargyl allows copper-catalyzed azide-alkyne cycloaddition, enabling precise attachment of cytotoxins for controlled ADC construction.
24/7/2017
We are interested in the stability considerations that apply to Propargyl-PEG6-NHS ester.
Propargyl-PEG6-NHS ester is sensitive to hydrolysis; it should be stored dry at low temperature and protected from moisture. Proper storage preserves reactivity and ensures reproducible ADC synthesis.
20/5/2022
Dear BOC Sciences, which payloads are compatible with Propargyl-PEG6-NHS ester?
Propargyl-PEG6-NHS ester is compatible with azide-functionalized payloads for click chemistry. Its PEG6 spacer enhances solubility, making it suitable for hydrophobic cytotoxins in ADC development.
14/5/2019
Good afternoon! What stability precautions are necessary for Propargyl-PEG6-NHS ester during storage?
Propargyl-PEG6-NHS ester should be stored at low temperature, preferably under inert gas and desiccated conditions. The NHS ester is susceptible to hydrolysis, so minimizing moisture exposure and limiting freeze-thaw cycles ensures consistent reactivity in ADC linker applications.
10/4/2018
— Dr. Jonathan White, Medicinal Chemist (UK)
Propargyl-PEG6-NHS ester provided high efficiency in click chemistry conjugations.
20/5/2022
— Ms. Anna Hoffmann, Biochemist (Germany)
Excellent lot-to-lot reproducibility allowed reliable multi-step synthesis.
10/4/2018
— Dr. William Parker, Senior Scientist (USA)
High yields with minimal by-products were achieved in all trials.
14/5/2019
— Dr. Elise Moreau, Chemist (France)
Integration into complex linker synthesis was straightforward and predictable.
3/9/2020
— Dr. Mark Johnson, Research Scientist (USA)
Propargyl-PEG6-NHS ester enabled exploration of novel PEGylated ADC linkers.
— Dr. Michael Evans, Bioconjugation Scientist (UK)
Propargyl-PEG6-NHS ester provided by BOC Sciences was highly reactive and consistent, making it ideal for our bioconjugation projects.
25/7/2017
Propargyl-PEG6-NHS ester
Required fields are marked with *
Propargyl-PEG6-NHS ester
Required fields are marked with *
Contact our experts today for pricing and comprehensive details on our ADC offerings.
From cytotoxin synthesis to linker design, discover our specialized services that complement your ADC projects.
Learn more about payload design, linker strategies, and integrated CDMO support through our curated ADC content.
Find exactly what your project needs from our expanded range of ADCs, offering flexible options to fit your timelines and goals.
