webinar
Oct. 27-28, 2025, Boston, MA, USA - Booth 114.
Read More

6-Maleimidocaproic acid sulfo-NHS

  CAS No.: 103848-61-9   Cat No.: BADC-00505   Purity: ≥98% 4.5  

6-Maleimidocaproic acid sulfo-NHS is a small molecule reagent used in the biomedical industry. It is commonly used to modify biomolecules, such as proteins and antibodies, for site-specific conjugation. This compound enables the efficient and stable attachment of drugs, tags, or targeting moieties to these biomolecules, thereby facilitating the development of innovative treatments for a variety of diseases, including cancer and autoimmune diseases.

6-Maleimidocaproic acid sulfo-NHS

Structure of 103848-61-9

Quality
Assurance

Worldwide
Delivery

24/7 Customer
Support
Category
ADC Linker
Molecular Formula
C14H16N2O9S
Molecular Weight
388.35
Shipping
Room temperature, or blue ice upon request.
Shipping
Please store the product under the recommended conditions in the Certificate of Analysis.

* For research and manufacturing use only. We do not sell to patients.

Size Price Stock Quantity
-- $-- In stock

Looking for different specifications? Click to request a custom quote!

Capabilities & Facilities

Popular Publications Citing BOC Sciences Products
Synonyms
N-[ε-maleimidocaproyloxy]sulfosuccinimide ester;
IUPAC Name
1-[6-(2,5-dioxopyrrol-1-yl)hexanoyloxy]-2,5-dioxopyrrolidine-3-sulfonic acid
Canonical SMILES
C1C(C(=O)N(C1=O)OC(=O)CCCCCN2C(=O)C=CC2=O)S(=O)(=O)O
InChI
InChI=1S/C14H16N2O9S/c17-10-5-6-11(18)15(10)7-3-1-2-4-13(20)25-16-12(19)8-9(14(16)21)26(22,23)24/h5-6,9H,1-4,7-8H2,(H,22,23,24)
InChIKey
NWHAVGHJSKQCHH-UHFFFAOYSA-N
Appearance
Soild powder
Shipping
Room temperature, or blue ice upon request.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.

6-Maleimidocaproic acid sulfo-NHS, a highly reactive crosslinking reagent, is extensively utilized in biochemical and biotechnological applications. Here are four key applications of this compound, presented with a high degree of perplexity and burstiness:

Protein Labeling: Serving as a fundamental tool in protein research, 6-Maleimidocaproic acid sulfo-NHS plays a crucial role in covalently attaching fluorescent dyes or other labels to proteins. By interacting with free amine groups on proteins, it facilitates precise and durable labeling essential for various analytical techniques like fluorescence microscopy and flow cytometry. This capability enhances the ability to monitor and analyze protein dynamics within diverse cellular environments, unveiling new dimensions in the exploration of protein function.

Antibody Conjugation: At the heart of therapeutic and diagnostic pursuits, this reagent is pivotal in skillfully conjugating antibodies with drugs, toxins, or enzymes. Through the formation of steadfast thioether bonds with sulfhydryl groups, it ensures targeted and effective delivery of the conjugated molecules. This application stands as a cornerstone in advancing targeted cancer therapies and developing diagnostic assays, ushering in new possibilities for precision medicine and disease detection.

Surface Immobilization: In the realms of biosensing and biochip technologies, 6-Maleimidocaproic acid sulfo-NHS emerges as a critical agent for immobilizing biomolecules onto various surfaces. By establishing a durable linkage between the biomolecule and the sensor surface, it enhances the sensitivity and specificity of biosensing devices. This functionality proves particularly crucial in creating diagnostic tools capable of detecting biomarkers and pathogens, heralding a new era in rapid and accurate disease diagnosis.

Protein-Protein Interaction Studies: Unveiling the intricacies of cellular signaling and molecular dynamics, this crosslinking reagent is invaluable for probing protein-protein interactions. By bridging proteins in close proximity, it empowers researchers to unravel and delineate intricate interaction networks crucial for understanding complex biological processes.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Related Products

Contact our experts today for pricing and comprehensive details on our ADC offerings.

You May Also Be Interested In

From cytotoxin synthesis to linker design, discover our specialized services that complement your ADC projects.

ADC Linker Development Enzyme Cleavable Linker Cathepsin B Cleavable Linker/Peptide Linker Phosphatase Cleavable Linker β-Glucuronide Linker β-Galactosidase Cleavable Linker Sulfatase Cleavable Linker Chemically Cleavable Linker Non-Cleavable Linker Services Acid Cleavable Linker/Hydrazone Linker

Unlock Deeper ADC Insights

Learn more about payload design, linker strategies, and integrated CDMO support through our curated ADC content.

Linkers - A Crucial Factor in Antibody–Drug Conjugates In-Depth Review of ADC Linkers: Types, Mechanisms, and Research Progress New Structural Insights Solve Instability Issues of Maleimide Linkers in ADCs PEG Linkers in Antibody-Drug Conjugates Peptide Linkers in Antibody-Drug Conjugates Disulfide Linkers in Antibody-Drug Conjugates Biotinylation Reagents in Antibody-Drug Conjugates Maleimide Linkers in Antibody-Drug Conjugates Current ADC Linker Chemistry SPDB Linkers in Antibody-Drug Conjugates

Explore More ADC Products

Find exactly what your project needs from our expanded range of ADCs, offering flexible options to fit your timelines and goals.

ADC Cytotoxin

Powerful Targeted Cancer Solutions

ADC  Cytotoxin with Linker

Enhanced Stability And Efficacy

ADC Linker

Precise Conjugation For Success

Antibody-Drug  Conjugates (ADCs)

Maximized Therapeutic Performance

Auristatins

Next-Level Tubulin Inhibition

Calicheamicins

High-Impact DNA Targeting

Camptothecins

Advanced Topoisomerase Inhibition

Daunorubicins / Doxorubicins

Trusted Anthracycline Payloads

Duocarmycins

Potent DNA Alkylation Agents

Maytansinoids

Superior Microtubule Disruption

Pyrrolobenzodiazepines

Ultra-Potent DNA Crosslinkers

Traditional Cytotoxic Agents

Proven Chemotherapy Solutions

Cleavable Linker

Precise Intracellular Drug Release

Non-Cleavable Linker

Exceptional Long-Term Stability

Historical Records: DBCO-PEG3 acetic-EVCit-PAB | Propargyl-PEG4-NHS ester | THP-SS-alcohol | Bis-PEG4-NHS ester | BCN-PEG4-NHS ester | 4-Formyl-N-(2-(3-isopropylphenoxy)ethyl)benzamide | N-Hydroxysuccinimidyl-4-azidobenzoate | Mc-Leu-Gly-Arg | 4-Formyl-N-(2-(mesityloxy)ethyl)benzamide | Mal-PEG5-NHS | 6-Maleimidocaproic acid sulfo-NHS
Send Inquiry
Verification code
Inquiry Basket