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Colchicine, a toxic plant-derived alkaloid extracted from plants of the genus Colchicum, inhibits microtubule polymerization (IC50 = 3.2 μM). It inhibits the growth of MCF-7 human breast carcinoma cells and has anti-inflammatory activity. Colchicine can lower body temperature, inhibit the respiratory center, enhance the effect of sympathomimetic drugs, constrict blood vessels, and raise blood pressure.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00004 | 1 g | $298 |
| NCT Number | Title | Condition Or Disease | Phase | Start Date | Sponsor | Status |
|---|---|---|---|---|---|---|
| NCT00000577 | Asthma Clinical Research Network (ACRN) | Asthma | Phase 3 | September 1993 | Milton S. Hershey Medical Center | Withdrawn |
| NCT00004368 | Phase I Study of Colchicine Therapy in Childhood Hepatic Cirrhosis | Cirrhosis | Phase 1 | May 1990 | National Center for Research Resources (NCRR) | Unknown status |
| NCT00004748 | Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis | Liver Cirrhosis, Biliary | Phase 3 | November 1989 | National Center for Research Resources (NCRR) | Completed |
| NCT00128414 | Study of Colchicine to Treat and Prevent Recurrent Pericarditis (First Episode) | Pericarditis | Phase 3 | August 2005 | Azienda Sanitaria Locale 3, Torino | Completed |
| NCT00128427 | Study of Colchicine to Prevent the Postpericardiotomy Syndrome | Postpericardiotomy Syndrome | Phase 3 | June 2005 | Azienda Sanitaria Locale 3, Torino | Completed |
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
