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CAS No.: 2252422-32-3
Cat No.: BADC-01537
Purity: 98%
4.5 
endo-BCN-PEG4-NHS ester is an NHS-activated ADC linker with bicyclo[6.1.0]non-4-yne (BCN) for strain-promoted click conjugation, enabling efficient and site-specific antibody modification for stable ADCs.
Structure of 2252422-32-3
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endo-BCN-PEG4-NHS ester is a versatile chemical reagent used in bioconjugation and biomedical research. Here are some key applications of endo-BCN-PEG4-NHS ester:
Protein Labeling: endo-BCN-PEG4-NHS ester is commonly used in protein labeling applications due to its ability to specifically react with amines on proteins. By targeting lysine residues, researchers can attach various probes, such as fluorescent dyes, facilitating protein tracking and visualization. This technique is essential for studying protein interactions and localization within cells.
Antibody Conjugation: In antibody conjugation, endo-BCN-PEG4-NHS ester serves as a critical linker between antibodies and other molecules, such as drugs or radioisotopes. This linkage allows for the targeted delivery of therapeutic agents to specific cells or tissues, enhancing treatment efficacy. The reagent’s specificity and stability make it ideal for developing antibody-drug conjugates (ADCs) for cancer therapy.
Drug Delivery Systems: endo-BCN-PEG4-NHS ester is utilized to modify nanoparticles and other drug carriers to improve their biocompatibility and targeting capabilities. By conjugating targeting ligands or therapeutic agents to drug delivery systems, researchers can create more effective treatments with reduced side effects. This application is particularly valuable in the development of targeted cancer therapies and personalized medicine approaches.
Biomolecule Surface Functionalization: The ester is also used in the functionalization of biomolecule surfaces to study interactions with cells and other biomolecules. By attaching specific functional groups to surfaces, researchers can create biomimetic environments to study cell behavior, adhesion, and differentiation. This approach is important for tissue engineering, regenerative medicine, and the development of biosensors.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00414 | endo-BCN-PEG4-PFP ester | 1421932-52-6 | |
| BADC-00418 | endo-BCN-PEG2-PFP ester | 1421932-53-7 | |
| BADC-01765 | endo-BCN-Fmoc-L-Lysine | 1493802-95-1 | |
| BADC-00416 | endo-BCN-PEG3-PFP ester | 2101206-48-6 | |
| BADC-00417 | endo-BCN-PEG3-NHS ester | 2101206-94-2 | |
| BADC-01259 | endo-BCN-PEG4-Val-Cit-PAB-MMAE |
What is endo-BCN-PEG4-NHS ester and its primary application in ADCs?
endo-BCN-PEG4-NHS ester is a bifunctional linker combining BCN (bicyclo[6.1.0]nonyne) and NHS ester functional groups. It enables efficient conjugation of payloads to antibodies through strain-promoted click chemistry and amine-reactive coupling, providing controlled and stable ADC synthesis.
29/12/2022
Could you explain how endo-BCN-PEG4-NHS ester improves conjugation efficiency?
The BCN moiety allows strain-promoted azide-alkyne cycloaddition without catalysts, while the NHS ester reacts with primary amines on antibodies. This dual functionality facilitates site-specific, high-yield conjugation, improving the consistency of ADC preparations.
7/2/2023
We would like to know the stability considerations for endo-BCN-PEG4-NHS ester.
endo-BCN-PEG4-NHS ester exhibits stability under dry, low-temperature conditions. Hydrolysis of the NHS ester can occur in aqueous environments, so it is recommended to store the linker under anhydrous conditions and minimize exposure to moisture prior to conjugation.
8/4/2019
Good afternoon! Which types of payloads are compatible with endo-BCN-PEG4-NHS ester?
This linker is compatible with payloads containing azide groups for click chemistry and primary amine groups for NHS ester coupling. It is suitable for small molecules, cytotoxins, and fluorescent dyes, providing versatility for a wide range of ADC applications.
5/12/2016
Dear team, what are the recommended storage conditions and stability considerations for endo-BCN-PEG4-NHS ester?
endo-BCN-PEG4-NHS ester should be stored at -20°C in a dry, inert atmosphere, preferably under nitrogen or argon. Repeated freeze-thaw cycles should be avoided to maintain its reactivity. Storage in aliquots is recommended to ensure consistent performance in bioconjugation applications.
20/5/2019
— Dr. Oliver Brown, Senior Scientist (UK)
endo-BCN-PEG4-NHS ester provided efficient strain-promoted cycloaddition reactions.
8/4/2019
— Ms. Clara Weber, Biochemist (Germany)
High purity and reproducibility enabled smooth multi-step linker synthesis.
20/5/2019
— Dr. Ethan Parker, Medicinal Chemist (USA)
We achieved excellent yields and minimal by-products in click conjugation.
5/12/2016
— Dr. Sophie Moreau, Senior Scientist (France)
Integration into ADC workflows was seamless and predictable.
29/12/2022
— Dr. Liam Fischer, Chemist (UK)
The reagent allowed development of innovative linkers improving solubility and stability.
— Prof. Daniel Brown, Medicinal Chemist (UK)
The endo-BCN-PEG4-NHS ester performed excellently in our strain-promoted azide-alkyne reactions. Documentation and handling guidelines were clear.
7/2/2023
endo-BCN-PEG4-NHS ester
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endo-BCN-PEG4-NHS ester
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