Name: Me-Tet-PEG3-Maleimide
Brand: BOC Sciences
Rating: 5 (1 reviews)

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IUPAC Name

3-(2,5-dioxopyrrol-1-yl)-N-[2-[2-[2-[3-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methylamino]-3-oxopropoxy]ethoxy]ethoxy]ethyl]propanamide

Canonical SMILES

CC1=NN=C(N=N1)C2=CC=C(C=C2)CNC(=O)CCOCCOCCOCCNC(=O)CCN3C(=O)C=CC3=O

InChI

InChI=1S/C26H33N7O7/c1-19-29-31-26(32-30-19)21-4-2-20(3-5-21)18-28-23(35)9-12-38-14-16-40-17-15-39-13-10-27-22(34)8-11-33-24(36)6-7-25(33)37/h2-7H,8-18H2,1H3,(H,27,34)(H,28,35)

InChIKey

GOTZKYCVLRMFON-UHFFFAOYSA-N

Me-Tet-PEG3-Maleimide, a versatile compound utilized in bioconjugation and molecular research, finds diverse applications in various fields.

Protein Conjugation: Me-Tet-PEG3-Maleimide plays a pivotal role in protein conjugation, forming robust thioether bonds with sulfhydryl groups on proteins or peptides. This unique property enables the creation of bioconjugates like antibody-drug conjugates used in targeted cancer therapies. Through the attachment of functional molecules to proteins, researchers can modulate protein characteristics and facilitate detection and purification processes.

Drug Delivery Systems: Within drug delivery research, Me-Tet-PEG3-Maleimide acts as a critical linker molecule for attaching therapeutic agents to polymer carriers. This linkage enhances the solubility and stability of drug molecules while enabling controlled release profiles in specific tissues. Incorporating Me-Tet-PEG3-Maleimide into nanocarriers enhances the efficacy and specificity of drug delivery systems, showcasing its versatility.

Biomedical Imaging: Me-Tet-PEG3-Maleimide contributes to the development of imaging agents requiring stable attachment of probes to biomolecules. Its specific conjugation with thiol groups allows precise labeling of proteins with fluorescent dyes or radioisotopes. This application is essential for non-invasive imaging techniques like PET or fluorescence microscopy, enabling real-time visualization of biological processes with intricate detail.

Surface Modification: In the realm of materials science, Me-Tet-PEG3-Maleimide is employed to enhance the biocompatibility and functionality of biomaterial surfaces. Grafting Me-Tet-PEG3-Maleimide onto surfaces introduces functional groups that deter protein adsorption or promote cell adhesion. This innovative surface modification enhances the performance of implants, biosensors, and medical devices, fostering superior integration with biological systems.