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| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01271 | -- | $-- | Inquiry |
Mal-PEG1-Val-Cit-OH, a versatile chemical linker essential in bioconjugation and drug development, finds diverse applications in various fields.
Antibody-Drug Conjugates (ADCs): Mal-PEG1-Val-Cit-OH plays a crucial role in the synthesis of antibody-drug conjugates, innovative cancer treatments that merge antibody specificity with potent cytotoxic drugs. This chemical serves as a robust linker that ensures controlled drug release specifically within the tumor microenvironment, enhancing the therapeutic efficacy of ADCs while minimizing harm to healthy tissues. The intricate interplay between antibodies and cytotoxic drugs mediated by Mal-PEG1-Val-Cit-OH underscores the precision of targeted cancer therapies.
Protein-Protein Conjugation: Within protein engineering, Mal-PEG1-Val-Cit-OH functions as a cross-linker, facilitating the connection between proteins or peptides for studying protein interactions and functions. This application is indispensable for generating complex biomolecules utilized in diagnostics and therapeutics. Through the strategic modification of proteins using this linker, researchers can bolster protein stability and activity while finely tuning their biological interactions. The versatile nature of Mal-PEG1-Val-Cit-OH in protein-protein conjugation underscores its significance in advancing biotechnological research.
Nanoparticle Functionalization: In the domain of nanotechnology, Mal-PEG1-Val-Cit-OH is instrumental in nanoparticle functionalization, enabling targeted delivery and controlled release of therapeutic agents. This capability is pivotal in constructing nanocarriers for drug delivery systems aimed at enhancing drug solubility and bioavailability. The inherent biocompatibility of Mal-PEG1-Val-Cit-OH ensures the stability of nanoparticles within biological environments, elevating their therapeutic effectiveness significantly.
Controlled Drug Release Systems: In the realm of pharmaceuticals, the adoption of Mal-PEG1-Val-Cit-OH in controlled drug delivery systems offers a method of tethering drugs to polymers or carriers for regulated drug release in response to specific stimuli like pH or enzymatic activity. This sophisticated mechanism ensures localized drug delivery precisely at the target site, enhancing treatment efficacy while reducing adverse effects.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
