Mc-Leu-Gly-Arg

Mc-Leu-Gly-Arg Catalog number: BADC-01281

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Mc-Leu-Gly-Arg is a cleavable ether linker for antibody-drug conjugates (ADC) design.

Category
ADCs Linker
Product Name
Mc-Leu-Gly-Arg
Catalog Number
BADC-01281
Molecular Formula
C21H34N6O6
Molecular Weight
466.53
Purity
≥95%

Ordering Information

Catalog Number Size Price Quantity
BADC-01281 -- $-- Inquiry
Description
Mc-Leu-Gly-Arg is a cleavable ether linker for antibody-drug conjugates (ADC) design.
Solubility
10 mm in DMSO
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature
Storage
-20°C

Mc-Leu-Gly-Arg, a peptide composed of leucine, glycine, and arginine, is a versatile compound with various applications in biochemistry, pharmacology, and biotechnology. Its unique sequence, featuring hydrophobic and positively charged amino acids, makes it particularly useful in peptide synthesis, drug development, and therapeutic research. The structure and properties of this peptide facilitate its use in targeting specific biological processes and improving the efficacy of pharmaceutical agents.

One significant application of Mc-Leu-Gly-Arg is in the field of drug delivery systems, particularly in the development of targeted therapies. The arginine residue, with its positive charge, interacts favorably with negatively charged cellular membranes or specific receptors, enabling the peptide to cross cell barriers more efficiently. This property is especially valuable in the design of peptide-based drugs that require precise targeting to specific cells or tissues, such as cancer cells or inflamed tissues. By modifying Mc-Leu-Gly-Arg, researchers can enhance the delivery of therapeutic agents directly to the desired site of action, increasing treatment efficacy and minimizing side effects.

Another key application of Mc-Leu-Gly-Arg is in the study of immune system modulation. The presence of arginine in the sequence can influence nitric oxide (NO) production, a critical signaling molecule involved in immune response and vascular function. Researchers use Mc-Leu-Gly-Arg to study its effects on immune cell activation, particularly in relation to cytokine production and macrophage function. This peptide has potential applications in immunotherapy, where it can be used to modulate immune responses to combat infections, inflammation, or even cancer.

Mc-Leu-Gly-Arg is also utilized in protein-protein interaction studies, particularly in the exploration of peptide-based inhibitors or activators. The leucine and arginine residues contribute to the peptide’s ability to mimic natural substrates or binding partners in biological systems. By studying Mc-Leu-Gly-Arg, researchers can identify new targets for drug development or gain insights into the molecular mechanisms governing critical cellular functions. This application is crucial in the development of small molecule inhibitors for diseases such as cancer, autoimmune disorders, and cardiovascular diseases.

Furthermore, Mc-Leu-Gly-Arg has important applications in biomaterials and tissue engineering. The sequence’s amphipathic nature, with hydrophobic leucine and hydrophilic glycine and arginine, allows it to interact with both aqueous environments and lipid membranes. This property is exploited in the design of biomaterials for scaffolds or coatings in regenerative medicine. These materials promote cell adhesion, proliferation, and differentiation, which are essential for tissue repair and regeneration. Mc-Leu-Gly-Arg can also be incorporated into drug delivery carriers, improving biocompatibility and ensuring controlled release of therapeutic agents.

Finally, Mc-Leu-Gly-Arg plays a role in diagnostics, particularly in the design of biosensors and molecular imaging probes. Its ability to bind to specific cellular targets makes it useful in the development of peptide-based probes for imaging or diagnostic applications. By attaching Mc-Leu-Gly-Arg to imaging agents, researchers can track peptide distribution within the body, providing valuable information for disease detection and monitoring treatment progress.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Tubulysin A | Mc-Leu-Gly-Arg
Why Choose BOC Sciences?

Customer Support

Providing excellent 24/7 customer service and support

Project Management

Offering 100% high-quality services at all stages

Quality Assurance

Ensuring the quality and reliability of products or services

Global Delivery

Ensuring timely delivery of products worldwide

Questions & Comments
Verification code
Send Inquiry
Verification code
Resources & Supports
Inquiry Basket