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H-L-Dbu(N3)-OH hydrochloride

  CAS No.:   Cat No.: BADC-01909 4.5  

H-L-Dbu(N3)-OH hydrochloride is an azide-bearing amino acid derivative ADC linker intermediate designed for click chemistry conjugation to enable precise payload attachment in antibody-drug conjugates. Keywords: ADC linker, azide linker, amino acid derivative, click chemistry, targeted therapy.

H-L-Dbu(N3)-OH hydrochloride

Structure of

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ADC Linker
Molecular Formula
C4H9ClN4O2
Molecular Weight
180.59

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IUPAC Name
(3S)-3-amino-4-azidobutanoic acid;hydrochloride
Canonical SMILES
C(C(CN=[N+]=[N-])N)C(=O)O.Cl
InChI
InChI=1S/C4H8N4O2.ClH/c5-3(1-4(9)10)2-7-8-6;/h3H,1-2,5H2,(H,9,10);1H/t3-;/m0./s1
InChIKey
VBRWTNQIWDBRCA-DFWYDOINSA-N

H-L-Dbu(N3)-OH hydrochloride, a peptide derivative with specialized applications in biochemical research and pharmaceutical development, presents a myriad of opportunities for innovation. Here are four key applications of H-L-Dbu(N3)-OH hydrochloride:

Peptide Synthesis: Serving as a fundamental pillar in the realm of peptide and protein synthesis, H-L-Dbu(N3)-OH hydrochloride boasts a distinctive azide group that catalyzes click chemistry reactions, ushering in a new era of bioconjugate and fluorescently labeled peptide synthesis for a plethora of biological assays and imaging endeavors. This intricate modification process unfurls a tapestry of possibilities for probing deep into the intricate functionalities and mechanisms of peptides using state-of-the-art methodologies.

Drug Development: Spearheading pharmaceutical advancements, H-L-Dbu(N3)-OH hydrochloride emerges as a pivotal cornerstone in the creation of novel peptide-based drugs. Its azide functionality facilitates the seamless integration of bioorthogonal handles, empowering the attachment of targeted drug delivery systems that enhance therapeutic precision and efficacy.

Bioconjugation: Venturing into the realm of bioconjugation, H-L-Dbu(N3)-OH hydrochloride stands as a pivotal link in connecting biomolecules such as proteins, nucleic acids, and antibodies. By incorporating the versatile azide group into biomolecular structures, researchers embark on a journey of click chemistry exploration, attaching diverse functional groups that unveil a realm of possibilities for biosensors, diagnostic tools, and precisely targeted therapies.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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