webinar
Oct. 27-28, 2025, Boston, MA, USA - Booth 114.
Read More

DACN(Tos,Ns)

  CAS No.: 1797508-58-7   Cat No.: BADC-01834 4.5  

DACN(Tos,Ns) is a maleimide-based ADC linker featuring tosylate and nosylate leaving groups, facilitating selective antibody cysteine conjugation with improved payload attachment and ADC stability.

DACN(Tos,Ns)

Structure of 1797508-58-7

Quality
Assurance

Worldwide
Delivery

24/7 Customer
Support
Category
ADC Linker
Molecular Formula
C20H21N3O6S2
Molecular Weight
463.53

* For research and manufacturing use only. We do not sell to patients.

Size Price Stock Quantity
-- $-- In stock

Looking for different specifications? Click to request a custom quote!

Capabilities & Facilities

Popular Publications Citing BOC Sciences Products
Synonyms
N-(o-nitrobenzenesulfonyl)-N'-(p-toluenesulfonyl)-4,8-diazacyclononyne
IUPAC Name
1-(4-methylphenyl)sulfonyl-5-(2-nitrophenyl)sulfonyl-1,5-diazacyclonon-7-yne
Canonical SMILES
CC1=CC=C(C=C1)S(=O)(=O)N2CCCN(CC#CC2)S(=O)(=O)C3=CC=CC=C3[N+](=O)[O-]
InChI
InChI=1S/C20H21N3O6S2/c1-17-9-11-18(12-10-17)30(26,27)21-13-4-5-14-22(16-6-15-21)31(28,29)20-8-3-2-7-19(20)23(24)25/h2-3,7-12H,6,13-16H2,1H3
InChIKey
XYCTXUMNSSJWLT-UHFFFAOYSA-N

DACN(TosNs), a versatile chemical reagent utilized in organic synthesis and biochemical research, offers a wide array of applications. Here are four key applications of DACN(TosNs)

Peptide Synthesis: A cornerstone of DACN(TosNs) application lies in peptide synthesis, where its ability to shield amino groups enables precise deprotection and coupling of amino acids, yielding intricate peptide sequences with exceptional efficiency. Researchers heavily rely on this reagent for crafting complex peptides essential for biological investigations and therapeutic advancements.

Protein Modification: Within the realm of biochemical exploration, DACN(TosNs) shines in protein modification by selectively labeling specific amino groups. This targeted alteration facilitates in-depth analysis of protein interactions, localization, and cellular functions. Notably, it aids in generating fluorescently labeled proteins crucial for imaging and tracking studies with remarkable precision.

Organic Chemistry Reactions: DACN(TosNs) stands as a pivotal tool in diverse organic synthesis reactions encompassing nucleophilic substitution and addition reactions. Its proficiency in creating stable intermediates elevates its significance in synthesizing intricate organic compounds spanning from pharmaceuticals to fine chemicals. Chemists leverage its capabilities to streamline synthetic pathways and attain pristine end products of superior purity.

Drug Development: Pharmaceutical innovators wield DACN(TosNs) in the pursuit of novel drug candidates, modifying lead compounds to optimize their pharmacological profiles. By safeguarding specific functional groups, this reagent enables strategic modifications that refine drug efficacy, stability, and safety profiles, critical in the iterative journey of drug discovery and enhancement.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Related Products

Contact our experts today for pricing and comprehensive details on our ADC offerings.

You May Also Be Interested In

From cytotoxin synthesis to linker design, discover our specialized services that complement your ADC projects.

ADC Linker Development Enzyme Cleavable Linker Cathepsin B Cleavable Linker Phosphatase Cleavable Linker β-Glucuronide Linker β-Galactosidase Cleavable Linker Sulfatase Cleavable Linker Chemically Cleavable Linker Non-Cleavable Linker Services Acid Cleavable Linker

Unlock Deeper ADC Insights

Learn more about payload design, linker strategies, and integrated CDMO support through our curated ADC content.

Linkers - A Crucial Factor in Antibody–Drug Conjugates In-Depth Review of ADC Linkers: Types, Mechanisms, and Research Progress New Structural Insights Solve Instability Issues of Maleimide Linkers in ADCs PEG Linkers in Antibody-Drug Conjugates Peptide Linkers in Antibody-Drug Conjugates Disulfide Linkers in Antibody-Drug Conjugates Biotinylation Reagents in Antibody-Drug Conjugates Maleimide Linkers in Antibody-Drug Conjugates Current ADC Linker Chemistry SPDB Linkers in Antibody-Drug Conjugates

Explore More ADC Products

Find exactly what your project needs from our expanded range of ADCs, offering flexible options to fit your timelines and goals.

ADC Cytotoxin

Powerful Targeted Cancer Solutions

ADC  Cytotoxin with Linker

Enhanced Stability And Efficacy

ADC Linker

Precise Conjugation For Success

Antibody-Drug  Conjugates (ADCs)

Maximized Therapeutic Performance

Auristatins

Next-Level Tubulin Inhibition

Calicheamicins

High-Impact DNA Targeting

Camptothecins

Advanced Topoisomerase Inhibition

Daunorubicins / Doxorubicins

Trusted Anthracycline Payloads

Duocarmycins

Potent DNA Alkylation Agents

Maytansinoids

Superior Microtubule Disruption

Pyrrolobenzodiazepines

Ultra-Potent DNA Crosslinkers

Traditional Cytotoxic Agents

Proven Chemotherapy Solutions

Cleavable Linker

Precise Intracellular Drug Release

Non-Cleavable Linker

Exceptional Long-Term Stability

Historical Records: DACN(Tos2,6-OH) | Boc-cis-L-4-hydroxyproline methyl ester | H-L-Dbu(N3)-OH HCl | Boc-Ser(O-propargyl)-OH (DCHA) | Boc-L-Phe(4-NH-Poc)-OH | Me-PMeOx(50)-N3 (MW 4.3kDa) | Z-AEVD-FMK | DACN(Tos) hydrochloride | (2R,4S)-Boc-D-Pro(4-N3)-OH (DCHA) | H-(Gly)3-Lys(N3)-OH HCl | DACN(Tos,Ns)
Send Inquiry
Verification code
Inquiry Basket