Alkyne-PEG2-iodide is a bifunctional ADC linker combining alkyne and iodide reactive groups with a PEG2 spacer. It facilitates click chemistry and nucleophilic substitution for selective and stable payload conjugation in antibody-drug conjugates.
Structure of 1234387-33-7
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Capabilities & Facilities
Alkyne-PEG2-iodide, a versatile chemical compound, finds myriad applications in bioconjugation and biochemical domains. Here are four key applications of Alkyne-PEG2-iodide, presented with high perplexity and burstiness:
Click Chemistry: Embracing the realm of click chemistry, Alkyne-PEG2-iodide emerges as a cornerstone, facilitating bioorthogonal reactions with finesse. By pairing with azide-functionalized molecules, it orchestrates the precise and exclusive labeling of biomolecules. This intricate dance enables the exploration of protein-protein interactions, delving into the inner workings of cellular processes, and forging paths in diagnostic tool development.
Drug Delivery: Harnessing the PEGylation prowess of Alkyne-PEG2-iodide, researchers delve into the realm of drug delivery systems, where this compound plays a pivotal role. Through strategic attachment to therapeutic agents, it elevates solubility, stability, and bioavailability of drugs, culminating in heightened therapeutic efficacy and mitigated side effects.
Immunoassays: Stepping into the arena of immunoassays, Alkyne-PEG2-iodide takes center stage, driving advancements in diagnostics and clinical research. Its application in modifying antibodies or antigens ushers in a new era of conjugation with reporter molecules like fluorophores or enzymes, enabling the detection of target analytes with precision. Immunoassays emerge as a linchpin in biomarker discovery, paving the way for groundbreaking insights in clinical settings.
Surface Functionalization: A pioneer in surface functionalization, Alkyne-PEG2-iodide empowers the field of biomaterials and nanoparticles. By introducing reactive alkyne groups, it sets the stage for subsequent conjugation with diverse ligands, such as peptides or oligonucleotides, heralding innovations in biosensor development, tissue engineering, and targeted drug delivery systems.
Catalog | Product Name | CAS | Inquiry |
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BADC-01205 | Alkyne-PEG4-SS-PEG4-alkyne | ||
BADC-01873 | Alkyne-PEG5-SNAP |
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