Name: 4-Pentynoyl-Val-Ala-PAB-PNP
Brand: BOC Sciences
Rating: 5 (1 reviews)

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IUPAC Name

[4-[[(2S)-2-[[(2S)-3-methyl-2-(pent-4-ynoylamino)butanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate

Canonical SMILES

CC(C)C(C(=O)NC(C)C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)CCC#C

InChI

InChI=1S/C27H30N4O8/c1-5-6-7-23(32)30-24(17(2)3)26(34)28-18(4)25(33)29-20-10-8-19(9-11-20)16-38-27(35)39-22-14-12-21(13-15-22)31(36)37/h1,8-15,17-18,24H,6-7,16H2,2-4H3,(H,28,34)(H,29,33)(H,30,32)/t18-,24-/m0/s1

InChIKey

HIHCCJAGZUJVAO-UUOWRZLLSA-N

4-Pentynoyl-Val-Ala-PAB-PNP, a synthetic peptide employed in diverse research and diagnostic contexts, offers a plethora of applications. Here are four key applications showcased with a high degree of perplexity and burstiness:

Protease Activity Assays: In protease activity assays, 4-Pentynoyl-Val-Ala-PAB-PNP serves as a ubiquitous substrate facilitating the measurement of specific protease activity within biological samples. By quantifying the cleavage of this substrate, researchers can delve into the intricate realm of protease function, unraveling potential protease inhibitors crucial for advancing drug discovery endeavors.

Biomarker Development: Redefining biomarker development, the synthetic essence of 4-Pentynoyl-Val-Ala-PAB-PNP renders it an optimal candidate for disease biomarkers linked to protease dysregulation. Its utility in diagnostic tests enables the detection of aberrant protease activity in patient samples, serving as a linchpin for the early detection and monitoring of conditions like cancer and inflammatory diseases.

Drug Screening: Within high-throughput screening platforms, 4-Pentynoyl-Val-Ala-PAB-PNP emerges as a pivotal tool for identifying and assessing potential protease inhibitors. By scrutinizing how candidate compounds interact with this peptide substrate, researchers embark on a quest to unearth effective inhibitors that may spearhead drug development, catalyzing the quest for novel therapeutics.

Enzyme Kinetics Studies: Powering enzyme kinetics studies, 4-Pentynoyl-Val-Ala-PAB-PNP unveils the intricate kinetic properties of proteolytic enzymes. Through a meticulous analysis of substrate cleavage rates, researchers unveil critical parameters like Km and Vmax, crucial for characterizing enzyme behavior and optimizing conditions tailored for industrial and medical applications at the forefront of scientific exploration.