Name: Alkyne-PEG5-SNAP
Brand: BOC Sciences
Rating: 5 (1 reviews)

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IUPAC Name

N-[[4-[(2-amino-7H-purin-6-yl)oxymethyl]phenyl]methyl]-3-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]propanamide

Canonical SMILES

C#CCOCCOCCOCCOCCOCCC(=O)NCC1=CC=C(C=C1)COC2=NC(=NC3=C2NC=N3)N

InChI

InChI=1S/C27H36N6O7/c1-2-8-35-10-12-37-14-16-39-17-15-38-13-11-36-9-7-23(34)29-18-21-3-5-22(6-4-21)19-40-26-24-25(31-20-30-24)32-27(28)33-26/h1,3-6,20H,7-19H2,(H,29,34)(H3,28,30,31,32,33)

InChIKey

DRDQOLYRBKZPKT-UHFFFAOYSA-N

Alkyne-PEG5-SNAP is a versatile chemical reagent used predominantly in bioconjugation and labeling applications. Here are some key applications of Alkyne-PEG5-SNAP:

Protein Labeling: Alkyne-PEG5-SNAP is widely used for site-specific labeling of proteins in biochemical and cellular studies. The SNAP-tag technology allows for efficient and selective covalent attachment of the Alkyne-PEG5 moiety to SNAP-tagged proteins. This enables the subsequent conjugation of various probes or fluorophores via click chemistry, aiding in protein tracking, localization, and interaction studies in live cells.

Drug Delivery: Alkyne-PEG5-SNAP can be employed in the development of targeted drug delivery systems. By conjugating therapeutic agents to SNAP-tagged proteins or peptides, researchers can achieve precise delivery to specific cell types or tissues. The PEGylation aspect of Alkyne-PEG5 enhances the solubility and stability of the conjugates, ultimately improving the pharmacokinetic properties of the drug.

Cell Surface Engineering: Alkyne-PEG5-SNAP is utilized in cell surface engineering to modify the cellular membrane with bioactive molecules. This technique involves labeling cell surface proteins with SNAP-tag and subsequently reacting them with Alkyne-PEG5 for click chemistry reactions. Such modifications can be used to study cell signaling, adhesion, and interactions with the extracellular environment, and for developing cell-based biosensors.

Biocompatible Hydrogels: Alkyne-PEG5-SNAP can be used in the fabrication of biocompatible hydrogels for tissue engineering and regenerative medicine applications. By incorporating Alkyne-PEG5 into hydrogel scaffolds, researchers can create highly tunable materials that support cell growth and differentiation. The SNAP-tag allows for functionalization with bioactive molecules, enhancing the hydrogels’ capabilities as cell culture platforms or implantable materials.