mDPR(Boc)-Val-Cit-PAB - CAS 2281797-55-3

mDPR(Boc)-Val-Cit-PAB - CAS 2281797-55-3 Catalog number: BADC-01094

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Category
ADCs Linker
Product Name
mDPR(Boc)-Val-Cit-PAB
CAS
2281797-55-3
Catalog Number
BADC-01094
Molecular Formula
C30H43N7O9
Molecular Weight
645.70
Purity
>98.0%

Ordering Information

Catalog Number Size Price Quantity
BADC-01094 -- $-- Inquiry
Canonical SMILES
CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)CO)NC(=O)C(CNC(=O)OC(C)(C)C)N2C(=O)C=CC2=O
InChI
InChI=1S/C30H43N7O9/c1-17(2)24(36-26(42)21(37-22(39)12-13-23(37)40)15-33-29(45)46-30(3,4)5)27(43)35-20(7-6-14-32-28(31)44)25(41)34-19-10-8-18(16-38)9-11-19/h8-13,17,20-21,24,38H,6-7,14-16H2,1-5H3,(H,33,45)(H,34,41)(H,35,43)(H,36,42)(H3,31,32,44)/t20-,21-,24-/m0/s1
InChIKey
MFRDXMXKXVDYPI-HFMPRLQTSA-N
Solubility
10 mm in DMSO
Appearance
Solid
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
-20°C (International: -20°C)
Storage
Store at -20 °C, keep in dry and avoid sunlight.
Form
Solid

mDPR(Boc)-Val-Cit-PAB, a specialized linker molecule utilized in drug development, particularly in the creation of antibody-drug conjugates (ADCs), boasts a diverse array of applications.

Antibody-Drug Conjugate Development: An integral component in the realm of ADC development, mDPR(Boc)-Val-Cit-PAB serves as the linchpin connecting potent cytotoxic drugs to specific antibodies. Engineered for stability in the bloodstream yet enabling precise drug release within target cancer cells, this linker facilitates targeted delivery, thus minimizing systemic toxicity and amplifying therapeutic efficacy.

Cancer Research: In the expansive landscape of cancer research, mDPR(Boc)-Val-Cit-PAB takes center stage as a tool for dissecting targeted drug delivery mechanisms. Researchers harness this linker to scrutinize the ability of ADCs to selectively transport chemotherapy drugs to cancerous cells while sparing healthy tissues. These inquiries are pivotal in advancing the development of safer and more potent cancer therapies.

Bioconjugation Techniques: At the nexus of bioconjugation techniques, mDPR(Boc)-Val-Cit-PAB emerges as a pivotal facilitator for attaching diverse bioactive molecules to antibodies or other targeting entities. Its versatility empowers the creation of intricate bioconjugates with far-reaching implications across diagnostics, therapeutic monitoring, and personalized medicine. This linker enhances the functional repertoire of conjugated molecules, broadening their applications in the dynamic realm of biomedical research.

Pharmaceutical Manufacturing: Within the sphere of pharmaceutical manufacturing, mDPR(Boc)-Val-Cit-PAB assumes a critical role in the synthesis of stable and efficacious drug conjugates. This linker guarantees the secure attachment of payloads during production, ensuring their integrity through formulation and storage. Such stability is paramount for upholding the potency and consistency of the final therapeutic product, thereby securing reliable and robust clinical outcomes.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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