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DACN(Tos,Suc-OH)

  CAS No.: 2109751-68-8   Cat No.: BADC-01812 4.5  

DACN(Tos,Suc-OH) is a maleimide-based ADC linker intermediate with tosylate and succinimide groups, facilitating selective cysteine conjugation for stable antibody-drug conjugate assembly and controlled payload delivery in targeted therapies.

DACN(Tos,Suc-OH)

Structure of 2109751-68-8

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ADC Linker
Molecular Formula
C18H22N2O5S
Molecular Weight
378.44

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IUPAC Name
4-[5-(4-methylphenyl)sulfonyl-1,5-diazacyclonon-7-yn-1-yl]-4-oxobutanoic acid
Canonical SMILES
CC1=CC=C(C=C1)S(=O)(=O)N2CCCN(CC#CC2)C(=O)CCC(=O)O
InChI
InChI=1S/C18H22N2O5S/c1-15-5-7-16(8-6-15)26(24,25)20-13-3-2-11-19(12-4-14-20)17(21)9-10-18(22)23/h5-8H,4,9-14H2,1H3,(H,22,23)
InChIKey
GXAZNIVCKZZIOG-UHFFFAOYSA-N

DACN(TosSuc-OH), a versatile chemical compound with diverse applications in biochemical research and industry, boasts a myriad of uses. Here are four key applications:

Chemical Synthesis: Serving as a pivotal intermediate in the synthesis of complex organic molecules, DACN(TosSuc-OH) showcases its reactivity and diverse functional groups. These attributes render it ideal for constructing intricate chemical structures in fields like medicinal chemistry and material science. This versatility expedites the advancement of novel drugs and cutting-edge materials, propelling innovation in the chemical realm.

Enzyme Inhibition Studies: Taking center stage in enzyme kinetics experiments, DACN(TosSuc-OH) emerges as a potent inhibitor that interacts with specific enzymes. This interaction aids researchers in delving into the mechanisms and regulatory roles of enzymes in biochemical pathways. Such profound insights are fundamental for unlocking new possibilities in drug discovery and comprehending the intricate metabolic controls governing biological processes.

Protein Profiling: In the realm of proteomics, DACN(TosSuc-OH) plays a crucial role in labeling or modifying proteins to streamline their identification and characterization processes. By facilitating mass spectrometric analysis of proteins, this compound enhances the precision of protein profiling endeavors. These applications stand as linchpins in biomarker discovery and disease diagnosis, shedding light on the complex world of protein interactions and functions.

Production of Biopolymers: Leveraging its unique chemical properties, DACN(TosSuc-OH) emerges as a valuable monomer in the synthesis of biopolymers with wide-ranging applications. These biopolymers find utility in the realm of biodegradable materials and medical devices, offering sustainable alternatives to conventional plastics. Through the utilization of DACN(TosSuc-OH), researchers and industries can contribute to the development of environmentally friendly solutions and sustainable medical technologies.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: DBCO-S-S-acid | Boc-PEG4-Val-Cit-PAB-OH | NHS-SS-Ph | 4-(4-Acetyl-phenoxy)-butyric acid | Alkyne-Val-Cit-PAB-PNP | (2R,10S)-10-Benzyl-2-cyclopropyl-23-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-6,9,12,15,18-pentaoxo-3-oxa-5,8,11,14,17-pentaazatricosanoic acid | Fmoc-PEG4-Val-Cit-PAB-OH | Tubulysin B | MC-vc-PAB-DMEA-(PEG2)-duocarmycin SA | N3-L-Dab(Fmoc)-OH | DACN(Tos,Suc-OH)
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