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CAS No.:
Cat No.: BADC-01215
Purity: ≥95%
4.5 
Amino-SS-PEG12-acid offers a long PEG12 cleavable ADC linker with disulfide bond and terminal amino/acid groups. This linker improves biocompatibility and facilitates precise payload release in ADC applications targeting tumor cells.
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Amino-SS-PEG12-acid is a functionalized polyethylene glycol (PEG) derivative used in bioconjugation and drug delivery applications. Here are some key applications of Amino-SS-PEG12-acid:
1 Bioconjugation: The amino group in Amino-SS-PEG12-acid facilitates the conjugation of biomolecules such as proteins, peptides, and antibodies. This process improves the solubility, stability, and bioavailability of the biomolecules. The PEGylation can also reduce immunogenicity and prolong the circulating half-life in the bloodstream.
2 Drug Delivery: Amino-SS-PEG12-acid is commonly used to create drug delivery systems that enhance the pharmacokinetic profiles of therapeutic agents. The PEGylation helps in achieving controlled release and targeted delivery, which reduces the frequency of dosage and minimizes side effects. Additionally, the cleavable disulfide bond can provide site-specific delivery, as it can be broken down under reductive conditions found in tumors or inside cells.
3 Surface Modification: This compound is used to modify the surfaces of nanoparticles, micelles, and other delivery vehicles to enhance their biocompatibility and targeting capabilities. The PEGylated surface reduces protein adsorption and opsonization, which helps evade the immune system. This application is crucial for developing stealth nanoparticles for use in diagnostics and therapy.
4 Biosensor Development: Amino-SS-PEG12-acid can be utilized in the development of biosensors by immobilizing sensing elements on various substrates. The PEGylation layer provides a hydrophilic environment that can minimize non-specific binding, improving the sensor’s accuracy and sensitivity. This application is essential for creating reliable diagnostic tools for detecting biomolecules and pathogens.
Amino-SS-PEG12-acid
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Amino-SS-PEG12-acid
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