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Cat No.: BADC-00423
Purity: 98%
4.5 
2,5-dioxopyrrolidin-1-yl 1-(cyclooct-2-ynyloxy)-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate is a bioorthogonal conjugation building block that provides a bioorthogonal click handle for modular click-chemistry workflows. The molecule can be used to introduce a click-reactive group onto an antibody, peptide, linker intermediate, or payload-containing component, depending on the chemistry of its second terminal functionality. Its additional reactive group is nhs/succinimidyl ester (amine-reactive) for antibody lysines/primary amines. Conjugation can be performed using spaac with dbco/bcn-functionalized partner or cuaac with terminal alkyne partner, depending the complementary handle. The sequence and orientation of the coupling steps should be selected according to the functional groups carried by the two conjugation partners.
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* For research and manufacturing use only. We do not sell to patients.
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2,5-Dioxopyrrolidin-1-yl 1-(cyclooct-2-ynyloxy)-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate, a compound of remarkable versatility, finds application across diverse domains of chemical and biological research. Let's explore its key applications with high perplexity and burstiness:
Bioconjugation: This compound serves as a pivotal linker in bioconjugation endeavors, facilitating the attachment of biomolecules like proteins, peptides, or antibodies to various entities such as drugs or imaging agents. Its versatile and reactive nature enables the formation of intricate bioconjugates for targeted drug delivery or diagnostic purposes. These resulting conjugates can significantly enhance the specificity and efficacy of therapeutic agents, ushering in a new era of precision medicine.
Drug Development: Within the realm of pharmaceutical research, 2,5-dioxopyrrolidin-1-yl 1-(cyclooct-2-ynyloxy)-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate emerges as a key building block for synthesizing novel therapeutic compounds. This compound's unique structure empowers chemists to venture into unexplored chemical territories, designing drugs with heightened potency and selectivity. Such innovative approaches hold promise for unearthing new treatments across a spectrum of diseases, including cancer and infectious diseases.
Surface Functionalization: The compound under scrutiny proves invaluable for enhancing the functionality and biocompatibility of biomaterials through surface modification. By anchoring it onto material surfaces, researchers can immobilize bioactive molecules, augment cell adhesion, or create anti-fouling surfaces. This capability is particularly advantageous in crafting medical implants, tissue engineering scaffolds, and biosensors that push the boundaries of medical technology and innovation.
2,5-dioxopyrrolidin-1-yl 1-(cyclooct-2-ynyloxy)-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate
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2,5-dioxopyrrolidin-1-yl 1-(cyclooct-2-ynyloxy)-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate
Required fields are marked with *
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