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Ald-PEG23-SPDP, a versatile crosslinker merging a polyethylene glycol (PEG) spacer with a cleavable disulfide bond, is a cornerstone in various bioconjugation scenarios. Here, explore four key applications presented with a high level of perplexity and burstiness:
Drug Delivery: Ald-PEG23-SPDP is harnessed by researchers for conjugating drugs with targeting molecules, enhancing the precision and efficacy of therapeutic interventions. The PEG spacer bolsters solubility and stability within the drug conjugate, while the cleavable disulfide bond governs controlled release within the designated environment. This advanced technology holds tremendous value in shaping targeted cancer therapies and revolutionizing precision medicines, reshaping the landscape of drug delivery.
Protein-Protein Crosslinking: In the realm of biochemical exploration, Ald-PEG23-SPDP plays a pivotal role in streamlining the crosslinking of proteins, facilitating the scrutiny of protein interactions. The PEG linker preserves the biological functionality of proteins by mitigating steric hindrances, while the reducible disulfide bond allows for subsequent separation if required. This application serves as a cornerstone for unraveling protein complexes and mapping intricate interaction networks, shedding light on the complex domain of protein interactions.
Antibody Conjugation: Ald-PEG23-SPDP emerges as a highly effective tool for modifying antibodies to create antibody-drug conjugates (ADCs) or tagging antibodies with detection markers. PEGylation diminishes immunogenicity and extends circulation duration, while the disulfide bond ensures controlled release of the drug or marker within target cells. Widely embraced in therapeutic and diagnostic settings, this technology offers remarkable specificity and mitigates adverse effects, heralding a transformative era in antibody conjugation strategies.
Biosensor Development: In the realm of biosensors, Ald-PEG23-SPDP plays a pivotal role in anchoring biorecognition elements like enzymes or antibodies onto sensor surfaces. The PEG spacer safeguards the functionality of the recognition element by creating a flexible and hydrophilic environment. The cleavable bond enables reversible or refreshed responses, making this crosslinker ideal for reusable and dynamic biosensing platforms.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
