Inquiry Basket
CAS No.:
Cat No.: BADC-01200
Purity: 98.0%
4.5 
Ald-PEG23-SPDP is a long-chain PEG linker with aldehyde and pyridyldithiol reactive groups, enabling site-specific, cleavable conjugation for stable and targeted antibody-drug conjugates.
Structure of
* For research and manufacturing use only. We do not sell to patients.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
Popular Publications Citing BOC Sciences Products
Ald-PEG23-SPDP, a versatile crosslinker merging a polyethylene glycol (PEG) spacer with a cleavable disulfide bond, is a cornerstone in various bioconjugation scenarios. Here, explore four key applications presented with a high level of perplexity and burstiness:
Drug Delivery: Ald-PEG23-SPDP is harnessed by researchers for conjugating drugs with targeting molecules, enhancing the precision and efficacy of therapeutic interventions. The PEG spacer bolsters solubility and stability within the drug conjugate, while the cleavable disulfide bond governs controlled release within the designated environment. This advanced technology holds tremendous value in shaping targeted cancer therapies and revolutionizing precision medicines, reshaping the landscape of drug delivery.
Protein-Protein Crosslinking: In the realm of biochemical exploration, Ald-PEG23-SPDP plays a pivotal role in streamlining the crosslinking of proteins, facilitating the scrutiny of protein interactions. The PEG linker preserves the biological functionality of proteins by mitigating steric hindrances, while the reducible disulfide bond allows for subsequent separation if required. This application serves as a cornerstone for unraveling protein complexes and mapping intricate interaction networks, shedding light on the complex domain of protein interactions.
Antibody Conjugation: Ald-PEG23-SPDP emerges as a highly effective tool for modifying antibodies to create antibody-drug conjugates (ADCs) or tagging antibodies with detection markers. PEGylation diminishes immunogenicity and extends circulation duration, while the disulfide bond ensures controlled release of the drug or marker within target cells. Widely embraced in therapeutic and diagnostic settings, this technology offers remarkable specificity and mitigates adverse effects, heralding a transformative era in antibody conjugation strategies.
Biosensor Development: In the realm of biosensors, Ald-PEG23-SPDP plays a pivotal role in anchoring biorecognition elements like enzymes or antibodies onto sensor surfaces. The PEG spacer safeguards the functionality of the recognition element by creating a flexible and hydrophilic environment. The cleavable bond enables reversible or refreshed responses, making this crosslinker ideal for reusable and dynamic biosensing platforms.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00396 | Ald-PEG4-PFP | 1324007-10-4 | |
| BADC-00397 | Ald-PEG4-NHS ester | 1353011-74-1 |
Ald-PEG23-SPDP
Required fields are marked with *
Ald-PEG23-SPDP
Required fields are marked with *
Contact our experts today for pricing and comprehensive details on our ADC offerings.
From cytotoxin synthesis to linker design, discover our specialized services that complement your ADC projects.
Learn more about payload design, linker strategies, and integrated CDMO support through our curated ADC content.
Find exactly what your project needs from our expanded range of ADCs, offering flexible options to fit your timelines and goals.
