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Cat No.: BADC-00421
Purity: 98%
4.5 
2,5-dioxopyrrolidin-1-yl 1-(cyclooct-2-ynyloxy)-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate is a bioorthogonal conjugation building block that provides a bioorthogonal click handle for modular click-chemistry workflows. The molecule can be used to introduce a click-reactive group onto an antibody, peptide, linker intermediate, or payload-containing component, depending on the chemistry of its second terminal functionality. Its additional reactive group is nhs/succinimidyl ester (amine-reactive) for antibody lysines/primary amines. Conjugation can be performed using spaac with dbco/bcn-functionalized partner or cuaac with terminal alkyne partner, depending the complementary handle. The sequence and orientation of the coupling steps should be selected according to the functional groups carried by the two conjugation partners.
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* For research and manufacturing use only. We do not sell to patients.
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2,5-Dioxopyrrolidin-1-yl 1-(cyclooct-2-ynyloxy)-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate, a highly intricate chemical compound, finds diverse applications in the realms of chemical biology and material science. Here are four key applications presented with high perplexity and burstiness:
Bioconjugation: Widely utilized in bioconjugation methodologies, this compound serves as a versatile linker for connecting biomolecules such as proteins, peptides, or nucleic acids to various substrates. Its reactivity enables the formation of stable covalent bonds, facilitating the attachment of biologically active molecules to polymers, nanoparticles, or surfaces. This pivotal role is essential for the development of targeted drug delivery systems and diagnostic tools, enhancing precision in biomedical applications.
Drug Delivery Systems: Employed as a fundamental element in creating intricate drug delivery systems, this compound acts as a crucial linker for binding therapeutic agents. By enabling the controlled release of drugs at specific sites within the body, it enhances the efficacy of treatment while minimizing potential side effects. This targeted delivery mechanism revolutionizes the field of pharmacology, paving the way for personalized and efficient medication administration.
Material Science: Within the domain of material science, this compound serves as a catalyst for surface modification and the creation of functionalized materials with tailored properties. Its usage extends to attaching bioactive molecules such as enzymes or antibodies to diverse substrates, augmenting their functional capabilities. This application drives innovation in developing cutting-edge biosensors, biochips, and other advanced diagnostic devices, revolutionizing the interface between biology and material engineering.
Chemical Biology Studies: At the intersection of chemical biology, this compound plays a pivotal role in probing protein interactions and enzyme mechanisms. By facilitating the linkage of small molecules or probes to proteins, researchers can delve into binding sites, reaction dynamics, and cellular processes with enhanced clarity. This investigative approach accelerates the discovery of novel drug targets and deepens our comprehension of intricate biochemical pathways, shaping the landscape of modern biological research.
2,5-dioxopyrrolidin-1-yl 1-(cyclooct-2-ynyloxy)-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate
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2,5-dioxopyrrolidin-1-yl 1-(cyclooct-2-ynyloxy)-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate
Required fields are marked with *
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