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A non-cleavable linker refers to a type of linker that remains stable in vivo and is resistant to enzymatic or chemical cleavage. Unlike cleavable linkers, non-cleavable linkers maintain stability in blood circulation, ensuring that the drug is not prematurely released in non-target tissues. The core feature of non-cleavable linkers is their ability to connect small-molecule drugs (cytotoxins) to monoclonal antibodies (mAbs) through stable covalent bonds, thereby optimizing the pharmacokinetic properties of antibody-drug conjugates (ADCs). Non-cleavable linkers are particularly suitable for ADC designs that require high target specificity and aim to minimize off-target toxicity. Because their release mechanism relies on antibody degradation within target cells, non-cleavable linkers are especially effective in enhancing ADC safety and improving the therapeutic index. BOC Sciences offers a variety of high-quality non-cleavable linker products, specifically designed for ADC research and production. Our offerings include commonly used thioether-based, maleimide-based, and other innovative linker chemistries, providing flexible solutions to meet diverse payload types, antibody structures, and target cell environments.
