Inquiry Basket
GMBS is a non-cleavable linker widely used in antibody-drug conjugation development. Its unparalleled efficacy stems from its chemical cross-linking ability, promoting the covalent binding of proteins, peptides, antibodies and countless other molecules. Notably, GMBS occupies a key position in the fields of drug delivery systems, diagnostics, and evolving bioconjugation technologies.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00506 | -- | $-- | Inquiry |
| NCT Number | Condition Or Disease | Phase | Start Date | Sponsor | Status |
|---|---|---|---|---|---|
| NCT00294580 | Malaria | Phase 4 | 2015-05-28 | Imperial College London | Completed |
| NCT01660646 | Tuberculosis | Not Applicable | 2018-03-22 | London School of Hygiene and Tropical Medicine | Completed |
| NCT01847872 | Poliomyelitis | Phase 4 | 2018-03-22 | London School of Hygiene and Tropical Medicine | Completed |
| NCT00944840 | Malaria | Phase 3 | 2017-01-26 | London School of Hygiene and Tropical Medicine | Completed |
| NCT04703608 | Covid-19 | Phase 3 | 2021-06-04 | London School of Hygiene and Tropical Medicine | Recruiting |
GMBS, also known as N-γ-Maleimidobutyryl-oxysuccinimide ester, stands out as a heterobifunctional crosslinker with widespread applications in bioscience research and development. Here are four key applications of GMBS:
Protein Crosslinking: A fundamental use of GMBS lies in linking proteins via their amine and thiol groups, leading to the formation of stable protein conjugates. This process is pivotal for investigating protein-protein interactions and constructing intricate macromolecular assemblies. By strategically crosslinking specific proteins, researchers can delve deep into interaction networks and unravel the multifaceted functions of proteins within biological systems.
Antibody Labeling: GMBS finds its place in antibody conjugation, facilitating the attachment of various labels like fluorescent dyes or enzymes to antibodies. This enables the creation of labeled antibodies, essential for applications in immunoassays, imaging, and diagnostics.
Drug Delivery Systems: Employing GMBS to crosslink drug molecules to carriers, such as nanoparticles or polymers, opens up avenues for targeted drug delivery. This innovative application plays a crucial role in enhancing the therapeutic index and minimizing drug side effects by directing them to specific tissues or cells.
Customer Support
Providing excellent 24/7 customer service and support
Project Management
Offering 100% high-quality services at all stages
Quality Assurance
Ensuring the quality and reliability of products or services
Global Delivery
Ensuring timely delivery of products worldwide
BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
