Azido-PEG2-PFP ester is a mixture of azide-functionalized polyethylene glycol (PEG) derivatives interleaved with pentafluorophenyl (PFP) ester moieties. This special compound is widely used as a coupling agent in the field of bioconjugation chemistry and shows unparalleled potential in efficient biomolecule modification. Whether proteins or peptides, azido-PEG2-PFP esters open up many possibilities for revolutionary applications, including drug delivery systems, targeted therapies, and transformative diagnostics.
Structure of 1393330-37-4
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Capabilities & Facilities
Azido-PEG2-PFP ester is a heterobifunctional ADC linker designed for bioorthogonal conjugation strategies. It contains an azide functional group for click chemistry and a pentafluorophenyl (PFP) ester for efficient reaction with antibody amines. The PEG2 spacer enhances solubility and reduces steric interference between the antibody and ADC cytotoxin.
In ADC linker design, the azide-PFP combination enables site-specific payload attachment and controlled drug-to-antibody ratios (DAR). The PEG2 segment provides flexibility, supporting efficient payload conjugation while maintaining antibody-antigen binding and ADC stability.
Azido-PEG2-PFP ester is compatible with a variety of cytotoxic payloads, including auristatins and maytansinoids. Its chemical stability under physiological conditions ensures that ADC payloads remain attached until reaching the target tumor environment.
This linker is commonly applied in ADC research for constructing conjugates with predictable pharmacokinetics, controlled payload release, and reliable antibody conjugation. Its combination of bioorthogonal reactivity and PEG2 flexibility supports diverse ADC design strategies.
Catalog | Product Name | CAS | Inquiry |
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BADC-00404 | Azido-PEG4-PFP ester | 1353012-00-6 | |
BADC-00406 | Azido-PEG3-PFP ester | 1807530-07-9 |
What is Azido-PEG2-PFP ester and its purpose in ADC synthesis?
Azido-PEG2-PFP ester is a pentafluorophenyl ester-functionalized PEG linker with an azide group, used for selective conjugation to antibodies or payloads. The PFP ester improves reactivity with amines, and the azide enables SPAAC click chemistry.
15/9/2020
Dear BOC Sciences, how does Azido-PEG2-PFP ester enable site-specific ADC conjugation?
The azide group reacts with cyclooctyne-functionalized molecules via strain-promoted azide-alkyne cycloaddition, allowing copper-free, site-specific conjugation, while the PFP ester reacts efficiently with primary amines to attach payloads.
7/12/2018
Dear BOC Sciences, which types of payloads can be conjugated using this linker?
Azido-PEG2-PFP ester can conjugate cytotoxins, peptides, and imaging probes. Its PEG2 spacer increases hydrophilicity, flexibility, and reduces steric hindrance, improving ADC pharmacokinetics and solubility.
9/10/2016
Good afternoon! Could you kindly share the recommended storage conditions for Azido-PEG2-PFP ester?
Store the compound in anhydrous solvents at low temperature (-20°C), protected from light and moisture, to maintain ester reactivity and prevent azide decomposition prior to conjugation.
23/4/2022
Dear BOC Sciences, what is the recommended handling procedure for Azido-PEG2-PFP ester to ensure safe usage?
Azido-PEG2-PFP ester should be handled in a well-ventilated laboratory with appropriate personal protective equipment. Avoid contact with heat and open flames. Storage in a cool, dry, and dark environment is advised, and the compound should be used promptly after opening to prevent hydrolysis or degradation.
1/8/2022
— Dr. Jonathan White, Medicinal Chemist (UK)
Azido-PEG2-PFP ester enabled highly efficient click chemistry conjugation in our ADC research.
9/10/2016
— Ms. Clara Hoffmann, Biochemist (Germany)
Excellent batch-to-batch reproducibility allowed seamless integration of Azido-PEG2-PFP ester into our workflow.
1/8/2022
— Dr. William Parker, Senior Scientist (USA)
Solubility and reactivity were outstanding, facilitating multi-step conjugation reactions.
23/4/2022
— Prof. Olivia Martinez, Bioconjugation Scientist (USA)
Azido-PEG2-PFP ester enabled rapid bioconjugation reactions with high efficiency. The product consistency was excellent.
15/9/2020
— Mr. Noah Brown, Bioconjugation Specialist (Canada)
QC documentation provided by BOC Sciences supported regulatory compliance and smooth ADC development.
— Dr. Richard Evans, Bioconjugation Scientist (USA)
The Azido-PEG2-PFP ester arrived with comprehensive quality documentation. Its high reactivity facilitated rapid bioconjugation in our workflow without side reactions.
7/12/2018
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