Inquiry Basket
| Catalog | Product Name | CAS Number |
|---|---|---|
| BADC-01388 | PROTAC BRD4 Degrader-10 | 2417370-49-9 |
| PROTAC BRD4 Degrader-10, a PROTAC connected by ligands for von Hippel-Lindau and BRD4, can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with DC50s of 1.3 and 18 nM, respectively. | Inquiry | |
| BADC-01389 | PROTAC BRD4 Degrader-11 | |
| PROTAC BRD4 Degrader-11 is a PROTAC linked by ligands for von Hippel-Lindau and BRD4. It is conjugated with STEAP1 and CLL1 antibodies to degrade BRD4 protein in PC3 prostate cancer cells with DC50s of 0.23 nM and 0.38 nM, respectively. | Inquiry | |
| BADC-01390 | PROTAC BRD4 Degrader-13 | 2417370-71-7 |
| PROTAC BRD4 Degrader-13, a PROTAC connected by ligands for von Hippel-Lindau and BRD4, can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with DC50s of 0.025 and 6.0 nM, respectively. | Inquiry | |
| BADC-01391 | Methotrexate monohydrate | 6745-93-3 |
| Methotrexate monohydrate is a DHhF reductase inhibitor that inhibits the enzyme dihydrofolate reductase and DNA synthesis. Therefore it is used to treat various cancers. | Inquiry | |
| BADC-01392 | 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4-hydroxy-9-methoxy-, (4S)- | 19685-10-0 |
| Possess high anti-cancer properties. | Inquiry | |
| BADC-01396 | Exatecan | 171335-80-1 |
| Exatecan is an inhibitor of DNA topoisomerase I, with an IC50 of 2.2 μM (0.975 μg/mL). It can be used to study cancer. | Inquiry | |
| BADC-01400 | Seco-DUBA | 1227961-59-2 |
| seco-DUBA hydrochloride is a cell-permeable pro-drug that is cleaved into the active toxin (DUBA) in intracellular lysosomes by proteases, after internalization. The payload then alkylates the DNA, causing DNA damage and cell death. | Inquiry | |
| BADC-01401 | DGN462 | 1394079-41-4 |
| DGN462 is a potent DNA alkylating agent with antitumor activity, such as against acute myeloid leukemia (AML). DGN462 can be used as an ADC toxin molecule to synthesize ADC. | Inquiry | |
| BADC-01405 | Exatecan hydrochloride | 144008-87-7 |
| Exatecan hydrochloride is the salt of Exatecan, which is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan is an inhibitor of DNA topoisomerase I. | Inquiry | |
| BADC-01436 | DC44 | 1354787-77-1 |
| DC44, a ADC cytotoxin, can be used in the synthesis of Antibody-drug Conjugate (ADC). DC44 can be used for the targeted treatment of cancer. | Inquiry | |
| BADC-01437 | Tolytoxin | 127999-44-4 |
| Tolytoxin, a bioactive metabolite from cyanobacteria, is a potent antifungal antibiotic, exhibiting MICs of 0.25-8 nmol. Tolytoxin is a cyanobacterial macrolide that targets actin by inhibition of its polymerization. Tolytoxin has cytotoxic effects in cancer cells. | Inquiry | |
| BADC-01440 | Dxd-D5 | |
| Dxd-D5 (Exatecan-D5 derivative for ADC) is a tritiated version of Dxd. Dxd is a potent DNA topoisomerase I inhibitor with IC50 of 0.31 μM, which can be used as a payload of an antibody drug-conjugated ADC (DS-8201a) targeting HER2. | Inquiry | |
| BADC-01441 | sulfo-DGN462 sodium | 1401203-09-5 |
| sulfo-DGN46 sodium can be degraded to DGN462 in culture medium and plasma. DGN462 is a potent DNA alkylating agent with antitumor activity, such as against acute myeloid leukemia (AML). | Inquiry | |
| BADC-01443 | 7-Aminomethyl-10-methyl-11-fluoro camptothecin | 2378616-23-8 |
| 7-Aminomethyl-10-methyl-11-fluoro camptothecin is a toxin molecule of MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (HY-132158, compound 21a), which can be used to synthesize camptothecin antibody Drug Conjugates (ADCs). | Inquiry | |
| BADC-01444 | MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin | 2414594-29-7 |
| MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a) is a camptothecin payload that can be conjugated with a monoclonal antibody (mAb) to synthesize a camptothecin antibody drug conjugate ( ADC). | Inquiry | |
| BADC-01445 | Methotrexate-d3 | 432545-63-6 |
| Methotrexate-d3 is the deuterated version of Methotrexate. Methotrexate (Amethopterin) is an antimetabolite and antifolate that inhibits dihydrofolate reductase, which prevents the conversion of folate to tetrahydrofolate and inhibits DNA synthesis. Methotrexate is also an immunosuppressant and antineoplastic agent used in rheumatoid arthritis and researched in various cancers (such as acute lymphoblastic leukemia). | Inquiry | |
| BADC-01447 | Paclitaxel D5 | 1129540-33-5 |
| Paclitaxel D5 is deuterium-labeled paclitaxel. Paclitaxel is a natural antineoplastic agent that stabilizes tubulin aggregation. | Inquiry | |
| BADC-01458 | SuO-Val-Cit-PAB-MMAE | |
| SuO-Val-Cit-PAB-MMAE is part of an antibody drug conjugate (drug-linker conjugate for ADC). Consists of the peptide SuO-Val-Cit-PAB linked to the antimitotic agent MMAE, a tubulin inhibitor. | Inquiry | |
| BADC-01459 | MC-betaglucuronide-MMAE-1 | 1703778-92-0 |
| MC-betaglucuronide-MMAE-1 is part of an antibody-drug conjugate consisting of tubulin polymerization inhibitor MMAE and degradable ADC linker MC-betaglucuronide. | Inquiry | |
| BADC-01460 | DBM-MMAF | 1810001-93-4 |
| DBM-MMAF is composed of linker DBM and toxic molecule MMAF, which can be used to prepare antibody-conjugated drugs. | Inquiry |
