Inquiry Basket
| Catalog | Product Name | CAS Number |
|---|---|---|
| BADC-00609 | Duocarmycin MB | 1613286-58-0 |
| Duocarmycin MB is an antibody drug conjugate (ADC) toxin that can be used against multidrug resistant cell lines. Duocarmycin is a DNA alkylating agent that binds in minor groove. | Inquiry | |
| BADC-00614 | DC1 | 169901-27-3 |
| DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is an ADC cytotoxic for the targeted treatment of cancer. | Inquiry | |
| BADC-00617 | MMAF sodium | 1799706-65-2 |
| MMAF sodium is a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective tubulin polymerization inhibitor and is used as an antitumor agent. | Inquiry | |
| BADC-00680 | DC1-SMe | 501666-85-9 |
| DC1-Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer. | Inquiry | |
| BADC-00681 | DC0-NH2 | 615538-51-7 |
| DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer drugs (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component. | Inquiry | |
| BADC-00687 | N-Me-L-Ala-maytansinol | 77668-69-0 |
| N-Me-L-Ala-maytansinol is a hydrophobic, cell permeable payload used in the preparation of antibody-drug conjugate (ADC). | Inquiry | |
| BADC-00574 | Lys-SMCC-DM1 | 1281816-04-3 |
| Lys-SMCC-DM1 is the active metabolite of DM1. DM1 is a tubulin inhibitor. | Inquiry | |
| BADC-00600 | Sulfo-PDBA-DM4 | 1461704-01-7 |
| Sulfo-PDBA-DM4 is a drug-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Sulfo-PDBA to make antibody drug conjugate (ADC). Sulfo-PDBA is a gluthatione cleavable linker. | Inquiry | |
| BADC-00601 | Mal-VC-PAB-DM1 | 1464051-44-2 |
| Mal-VC-PAB-DM1 is a drug-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker Mal-VC-PAB. | Inquiry | |
| BADC-00633 | MC-Val-Cit-PAB-duocarmycin | 2055896-98-3 |
| MC-Val-Cit-PAB-duocarmycin is a drug-linker conjugate for ADC with potent antitumor activity by using duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB. | Inquiry | |
| BADC-00666 | MAC glucuronide phenol-linked SN-38 | 2246380-69-6 |
| MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) drug linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively. | Inquiry | |
| BADC-00667 | MAC glucuronide α-hydroxy lactone-linked SN-38 | 2246380-70-9 |
| MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 drug linker. MAC glucuronide α-hydroxy lactone-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 99 and 105 ng/mL, respectively. | Inquiry | |
| BADC-00670 | Mal-PEG4-VA-PBD | 2259318-50-6 |
| Mal-PEG4-VA-PBD is a drug-linker conjugate for ADC by using the antitumor antibiotic, Pyrrolobenzodiazepine (PBD), linked via Mal-PEG4-VA. | Inquiry | |
| BADC-00685 | MCC-Modified Daunorubicinol | 721945-30-8 |
| Daunorubicinol is a drug-linker conjugate for ADC with potent antitumor activity by using Aur0101 (DNA Topoisomerase II inhibitor), linked via the ADC linker. | Inquiry | |
| BADC-00715 | Boc-Val-Dil-Dap-OH | 1415246-54-6 |
| Boc-Val-Dil-Dap-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). | Inquiry | |
| BADC-00716 | Boc-Val-Dil-Dap-Phe-OMe | |
| Boc-Val-Dil-Dap-Phe-OMe is a cytotoxin for antibody-drug-conjugation (ADC). | Inquiry | |
| BADC-00717 | Boc-Val-Dil-Dap-Doe | 135383-62-9 |
| Boc-Val-Dil-Dap-Doe is a compound used to synthesize Dolastatin 10. Dolastatin 10 is a potent cytotoxin and involves inhibition of tubulin polymerization, tubulin-dependent guanosine triphosphate hydrolysis, and nucleotide exchange. | Inquiry | |
| BADC-00718 | Boc-Val-Dil-Dap-Nrp | |
| Boc-Val-Dil-Dap-Nrp is a cytotoxin for antibody-drug-conjugation (ADC). | Inquiry | |
| BADC-00719 | Tubulysin IM-1 | |
| Tubulysin IM-1 is an ADC Cytotoxin and it is also a tubulin binder used as anti-microtubule toxin. | Inquiry | |
| BADC-00720 | Tubulysin IM-2 | |
| Tubulysin IM-2 can be used in the synthesis of Tubulysin M. Tubulysin M is a Tubulysin D is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Tubulysin M is used as the cytotoxin in antibody-drug conjugates | Inquiry |
