Inquiry Basket
| Catalog | Product Name | CAS Number |
|---|---|---|
| BADC-01387 | PROTAC BRD4 Degrader-12 | 2417370-90-0 |
| PROTAC BRD4 Degrader-12, a PROTAC connected by ligands for von Hippel-Lindau and BRD4, can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with DC50s of 0.39 and 0.24 nM, respectively. | Inquiry | |
| BADC-01381 | Taltobulin hydrochloride | |
| Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic tripeptide cysteine analog, Taltobulin is a potent antimicrotubule that circumvents P-glycoprotein-mediated drug resistance in vitro and in vivo sex. Taltobulin hydrochloride inhibits purified tubulin polymerization, disrupts microtubule organization in cells, and induces mitotic arrest and apoptosis. | Inquiry | |
| BADC-01384 | Aminohexylgeldanamycin hydrochloride | 1146534-45-3 |
| Aminohexylgeldanamycin (AHGDM) hydrochloride, a derivative of Geldanamycin, is a heat shock protein 90 (HSP90) inhibitor. Aminohexylgeldanamycin hydrochloride has anti-angiogenic and anti-tumor activities. | Inquiry | |
| BADC-01396 | Exatecan | 171335-80-1 |
| Exatecan is an inhibitor of DNA topoisomerase I, with an IC50 of 2.2 μM (0.975 μg/mL). It can be used to study cancer. | Inquiry | |
| BADC-01382 | Fmoc-MMAE | 474645-26-6 |
| Fmoc-MMAE is a protective group-conjugated monomethyl auristatin E (MMAE) and a potent tubulin inhibitor. | Inquiry | |
| BADC-01378 | S-methyl DM1 | 912569-84-7 |
| S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds tubulin with a Kd of 0.93 μM and inhibits microtubule polymerization. S-methyl DM1 can effectively inhibit microtubule dynamic instability and has anticancer effects. | Inquiry | |
| BADC-01445 | Methotrexate-d3 | 432545-63-6 |
| Methotrexate-d3 is the deuterated version of Methotrexate. Methotrexate (Amethopterin) is an antimetabolite and antifolate that inhibits dihydrofolate reductase, which prevents the conversion of folate to tetrahydrofolate and inhibits DNA synthesis. Methotrexate is also an immunosuppressant and antineoplastic agent used in rheumatoid arthritis and researched in various cancers (such as acute lymphoblastic leukemia). | Inquiry | |
| BADC-01348 | Val-Cit-PAB-MMAE TFA salt | 1608127-32-7 |
| Val-Cit-PAB-MMAE TFA salt, a tubulin polymerase inhibitor, is a drug-linker conjugate for ADC. It contains an ADC linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE. | Inquiry | |
| BADC-01351 | Maytansinoid B | 1628543-40-7 |
| Maytansinoid B is a kind of ADC Cytotoxin. Maytansinoids are potent microtubule-targeted compounds that inhibit proliferation of cells at mitosis. It is used as the cytotoxic component in antibody-drug conjugates. | Inquiry | |
| BADC-01352 | Glucocorticoid receptor agonist-1 Ala-Ala-Mal | 2166376-51-6 |
| Glucocorticoid receptor agonist-1 Ala Ala Mal is a glucocorticoid that is also an agonist of the glucocorticoid receptor. The glucocorticoid receptor agonist-1Ala Ala Mal can be used to prepare ADC. | Inquiry | |
| BADC-01353 | SG3199 | 1595275-71-0 |
| SG3199 is a cytotoxic DNA minor groove interchain cross-linked PDB dimer. SG3199 is a component of ADC payload Tesirine (SG3249). | Inquiry | |
| BADC-01400 | Seco-DUBA | 1227961-59-2 |
| seco-DUBA hydrochloride is a cell-permeable pro-drug that is cleaved into the active toxin (DUBA) in intracellular lysosomes by proteases, after internalization. The payload then alkylates the DNA, causing DNA damage and cell death. | Inquiry | |
| BADC-01356 | SC209 | 1977557-86-0 |
| SC209 is an ADC cytotoxic used to synthesize anti-EGFR antibody-drug conjugate ADC. SC209 is a metabolite of STRO-002. | Inquiry | |
| BADC-01357 | PNU-159682 carboxylic acid | 1204819-92-0 |
| PNU-159682 carboxylic acid (compound 53) is a potent ADC cytotoxin encoding a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. PNU-159682 carboxylic acid is involved in protein folding and diverse functions such as cell adhesion, cell signaling, glycoprotein turnover, and roles in inflammation and immune responses. | Inquiry | |
| BADC-01358 | DMEA-PNU-159682 | 1799421-48-9 |
| DMEA-PNU-159682 (molecule D12) is an ADC cytotoxic molecule consisting of neomycin metabolite (MMDX) from liver microsomes and the potent ADC cytotoxin PNU-159682. | Inquiry | |
| BADC-01359 | Anticancer agent 81 | |
| Anticancer agent 81 can induce DNA damage and lead to tumor cell cycle arrest and apoptosis. It is used as a payload to conjugate with trastuzumab to obtain the antibody-drug conjugate (ADC) T-PBA. T-PBA maintained its mode of target and internalization ability of trastuzumab. | Inquiry | |
| BADC-01360 | Daunorubicin citrate | 1884557-85-0 |
| Daunorubicin citrate is a topoisomerase II inhibitor that intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair RNA and protein synthesis. It is used to treat cancer. | Inquiry | |
| BADC-01361 | Duostatin 5 | 2124210-34-8 |
| Duostatin 5 is a cytotoxin similar to dolastatin, and it has the advantages of simple synthesis and stability. | Inquiry | |
| BADC-01363 | Dideoxy-amanitin | 58255-46-2 |
| Dideoxy-amanitin is an α-Amanitin derivative. α-Amanitin is an extremely toxic bicyclic octapeptide isolated from the death-cap mushroom, Amanita phalloides. As a potent inhibitor of RNA polymerase II, α-amanitin is toxic to eukaryotic cells. | Inquiry | |
| BADC-01364 | TAM470 | 1802498-63-0 |
| TAM470 is an ADC cytolysin, inhibiting tubulin polymerization and depolymerization. TAM470 can be used in the synthesis of OMTX705 that is a novel FAP-targeting ADC demonstrates activity in chemotherapy and pembrolizumab-resistant solid tumor models. | Inquiry |
