Inquiry Basket
| Catalog | Product Name | CAS Number |
|---|---|---|
| BADC-00334 | Seco-DuocarmycinDMA | |
| Seco-Duocarmycin DMA is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates. | Inquiry | |
| BADC-00335 | DC-1 | |
| DC-1 is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates. | Inquiry | |
| BADC-00336 | Seco-Duocamycin GA | 1613286-59-1 |
| Seco-Duocarmycin GA is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates. | Inquiry | |
| BADC-00337 | Seco-Duocarmycin TM | 1142188-60-0 |
| Seco-Duocarmycin TM is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates. | Inquiry | |
| BADC-00338 | Auristatin T | 1799603-53-4 |
| A microtubule-disrupting agent. | Inquiry | |
| BADC-00129 | Pentazolone hydrochloride | 21314-60-3 |
| Synthetic, an inhibitor of monoamine oxydase.Enhances the toxicity of the Phenamine group and of Tryptamine. | Inquiry | |
| BADC-01377 | Pyrrolobenzodiazepine (PBD) | 945490-09-5 |
| Pyrrolobenzodiazepines are a class of natural products with antibiotic or anti-tumor properties. They are produced by various actinomycetes. As a class of DNA-crosslinking agents, pyrrolobenzodiazepines are significantly more potent than systemic chemotherapeutic drugs. | Inquiry | |
| BADC-00792 | Illudin M | 1146-04-9 |
| Illudin M is a natural sesquiterpene agent with strong anti-tumour activity. | Inquiry | |
| BADC-00635 | MMAE-[d8] | 2070009-72-0 |
| MMAE-[d8] is a labelled analogue of MMAE, which is a potent mitotic inhibitor and a tubulin inhibitor. | Inquiry | |
| BADC-00775 | FR-901464 | 146478-72-0 |
| It is a potent cell cycle inhibitor isolated from Pseudomonas sp. No.2663. It exhibits potent antitumor activities against tumor cell lines via binding to the spliceosome and modulating pre-mRNA splicing. | Inquiry | |
| BADC-00004 | Colchicine | 64-86-8 |
| Colchicine, a toxic plant-derived alkaloid extracted from plants of the genus Colchicum, inhibits microtubule polymerization (IC50 = 3.2 μM). It inhibits the growth of MCF-7 human breast carcinoma cells and has anti-inflammatory activity. Colchicine can lower body temperature, inhibit the respiratory center, enhance the effect of sympathomimetic drugs, constrict blood vessels, and raise blood pressure. | Inquiry | |
| BADC-00184 | Tubulysin A | 205304-86-5 |
| Tubulysin A is a novel antibiotic, which exhibits anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative activity. Tubulysins show very high cytotoxic activity against in vitro and in in vivo tumor models, especially against resistant tumor cell lines. Many representatives of these natural products are several orders of magnitude more potent than other available chemotherapeutics. | Inquiry | |
| BADC-00223 | Duocarmycin A | 118292-34-5 |
| It is produced by the strain of (Pyridamycin) Streptomyces sp. DO-88. It has strong antibacterial and antitumor activity. It can inhibit gram-positive bacteria such as Staphylococcus aureus and Streptococcus faecalis (MIC is less than 0.01 μg/mL), it can also inhibit klebsiella pneumoniae (MIC is 0.032 μg/mL), other bacteria and yeast (MIC is 1-10 μg/mL). | Inquiry | |
| BADC-01379 | Eribulin | 253128-41-5 |
| Eribulin suppressed centromere dynamics at concentrations that arrest mitosis. At 60 nmol/L eribulin (2 x mitotic IC(50)), the relaxation rate was suppressed 21%, the time spent paused increased 67%, and dynamicity decreased 35% (but without reduction in mean centromere separation), indicating that eribulin decreased normal microtubule-dependent spindle tension at the kinetochores, preventing the signal for mitotic checkpoint passage. [(3)H]eribulin binds soluble tubulin at a single site; however, this binding is complex with an overall K(d) of 46 microM, but also showing a real or apparent very high affinity (K(d) = 0.4 microM) for a subset of 25% of the tubulin. Eribulin also binds microtubules with a maximum stoichiometry of 14.7 +/- 1.3 molecules per microtubule (K(d) = 3.5 microM), strongly suggesting the presence of a relatively high-affinity binding site at microtubule ends. At 100 nM, the concentration that inhibits microtubule plus end growth by 50%, we found that one molecule of eribulin is bound per two microtubules, indicating that the binding of a single eribulin molecule at a microtubule end can potently inhibit its growth. Eribulin does not suppress dynamic instability at microtubule minus ends. Eribulin's in vivo superiority derives from its ability to induce irreversible mitotic blockade, which appears related to persistent drug retention and sustained Bcl-2 phosphorylation. | Inquiry | |
| BADC-00088 | Nemorubicin | 108852-90-0 |
| Nemorubicin, is a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile. The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives. | Inquiry | |
| BADC-00569 | Cryptophycin 1 | 124689-65-2 |
| Cryptophycin 1, produced by Nostoc sp. GSV 224, is a potent cytotoxic anti-microtubule agent. Cryptophycin 1 can induce cell apoptosis, and has anti-tumor activity and excellent anti-proliferation ability. | Inquiry | |
| BADC-00575 | (+)-CBI-CDPI1 | 128300-14-1 |
| (+)-CBI-CDPI1 is an enhanced functional analog of CC-1065. It is also a DNA alkylating agent that acts as an antibody drug conjugate (ADC) toxin. | Inquiry | |
| BADC-00593 | Apaziquone | 141304-51-0 |
| Apaziquone is an indolequinone bioreductive prodrug and analog of mitomycin C with potential antineoplastic and radiosensitization activities. Apaziquone is converted to active metabolites in hypoxic cells by intracellular reductases, which are present in greater amounts in hypoxic tumor cells. The active metabolites alkylate DNA, resulting in apoptotic cell death. | Inquiry | |
| BADC-00605 | Duocarmycin TM | 157922-77-5 |
| Duocarmycin TM is an exceptionally potent antitumor antibiotic. Duocarmycin TM is a DNA alkylator. | Inquiry | |
| BADC-01394 | DXD | 1599440-33-1 |
| DXD, an Exatecan derivative for ADC, is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 μM. It can be used as a payload for antibody-conjugated drug ADCs targeting HER2. | Inquiry |
