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Daunorubicinol is a drug-linker conjugate for ADC with potent antitumor activity by using Aur0101 (DNA Topoisomerase II inhibitor), linked via the ADC linker.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00685 | -- | $-- | Inquiry |
MCC-Modified Daunorubicinol represents a significant advancement in the field of antibody-drug conjugates (ADCs) for targeted cancer therapy. By harnessing the unique properties of daunorubicinol and enhancing its delivery through a strategically engineered ADC linker, this compound aims to improve the efficacy and safety profile of cancer treatments. The MCC (Maleimide Compound Conjugation) modification is integral in optimizing the conjugation efficiency and stability of the drug, thereby offering a superior therapeutic index compared to traditional chemotherapeutic agents
The primary application of MCC-Modified Daunorubicinol lies in its ability to selectively target and destroy malignant cells while minimizing collateral damage to healthy tissues. This targeting is achieved through the precise conjugation of the drug to antibodies that recognize and bind specific antigens expressed on the surface of cancer cells. Once bound, the conjugate is internalized into the cancer cell, where it releases daunorubicinol, a potent inhibitor of DNA Topoisomerase II, disrupting DNA replication and triggering apoptosis. This targeted approach significantly reduces systemic toxicity and enhances antitumor efficacy, making MCC-Modified Daunorubicinol a promising candidate for treating various aggressive cancers that overexpress these antigens
In addition to its direct antitumor effects, MCC-Modified Daunorubicinol has potential applications in overcoming multidrug resistance—a major hurdle in cancer therapy. The highly specific targeting mechanism allows this ADC to bypass traditional drug efflux pathways employed by cancer cells to resist treatment. By delivering daunorubicinol directly into the cancer cell, MCC-Modified Daunorubicinol can effectively counteract resistance mechanisms, thereby restoring the sensitivity of cancer cells to therapy. This makes the drug particularly useful in treating relapsed or refractory cancers, where existing treatments have failed
Furthermore, MCC-Modified Daunorubicinol is being explored for use in combination therapies, where it can be paired with other therapeutic agents to enhance anticancer effects. The precision targeting capability of MCC-Modified Daunorubicinol allows for synergistic interactions when used alongside traditional therapies such as radiation or other chemotherapeutic agents. Such combinations can lead to improved patient outcomes by maximizing tumor cell kill rates while reducing the required dosage of each agent, thereby decreasing the risk of adverse side effects
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
