Daunorubicin hydrochloride is a classic ADC payload intercalating DNA and inhibiting topoisomerase II, inducing apoptosis. It remains a valuable ADC cytotoxin for targeted hematologic and solid tumor therapies.
Structure of 23541-50-6
* For research and manufacturing use only. We do not sell to patients.
Size | Price | Stock | Quantity |
---|---|---|---|
1 g | $439 | In stock |
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Capabilities & Facilities
NCT Number | Condition Or Disease | Phase | Start Date | Sponsor | Status |
---|---|---|---|---|---|
NCT01802333 | Acute Myeloid Leukemia | Phase 3 | 2018-12-19 | National Cancer Institute (NCI) | Completed |
NCT00085124 | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 3 | 2013-06-05 | National Cancer Institute (NCI) | Completed |
NCT00474006 | ACUTE MYELOGENOUS LEUKEMIA | Phase 3 | 2011-06-10 | Cooperative Study Group A for Hematology | Completed |
NCT01806571 | Untreated Adult Acute Myeloid Leukemia | Phase 2 | 2020-08-18 | Mayo Clinic | Completed |
NCT02971397 | Acute Myeloid Leukemia | Phase 2 | 2018-11-02 | Wake Forest University Health Sciences | Unknown Verified November 2018 by Wake Forest University Health Sciences. Recruitment status was Active, not recruiting |
Daunorubicin hydrochloride is an anthracycline antibiotic and a potent ADC cytotoxin used as an ADC payload in antibody-drug conjugates. Its cytotoxic mechanism involves intercalation into DNA, inhibition of topoisomerase II, and generation of reactive oxygen species (ROS), resulting in DNA strand breaks, replication arrest, and induction of apoptosis in proliferating tumor cells. The hydrochloride salt form enhances solubility and chemical stability, allowing efficient conjugation to monoclonal antibodies through cleavable or non-cleavable linker chemistries. This enables controlled intracellular delivery in targeted ADC applications.
In antibody-drug conjugates, Daunorubicin hydrochloride is covalently linked to antibodies using linker strategies designed to maintain stability in systemic circulation while enabling selective payload release inside target cells. The ADC remains inactive during circulation, reducing off-target cytotoxicity. Upon internalization via receptor-mediated endocytosis, enzymatic or chemical cleavage of the linker releases the active daunorubicin payload. The released compound intercalates into nuclear DNA, inhibits topoisomerase II activity, and induces apoptosis, providing site-specific cytotoxic activity in antigen-expressing tumor cells.
Applications of Daunorubicin hydrochloride include its integration into ADCs targeting hematologic malignancies such as leukemia and lymphoma, as well as solid tumors expressing specific antigens. Its chemical compatibility with diverse linker systems allows optimization of conjugation efficiency, intracellular release kinetics, and pharmacokinetic behavior. Daunorubicin hydrochloride exhibits defined cytotoxic activity in target-expressing tumor cells and supports the development of ADCs with precise mechanisms of DNA damage and apoptosis induction, providing a controlled approach for tumor-targeted therapy in antibody-drug conjugate development.
Catalog | Product Name | CAS | Inquiry |
---|---|---|---|
BADC-01360 | Daunorubicin citrate | 1884557-85-0 | |
BADC-00042 | Daunorubicin | 20830-81-3 | |
BADC-00039 | Doxorubicin | 23214-92-8 | |
BADC-00685 | MCC-Modified Daunorubicinol | 721945-30-8 |
What is Daunorubicin hydrochloride?
Daunorubicin hydrochloride is an anthracycline cytotoxin that intercalates DNA and inhibits topoisomerase II. It is widely used as an ADC payload for targeted cancer therapy due to its potent DNA-damaging activity when delivered via antibody conjugates.
16/2/2020
Dear BOC Sciences, how does Daunorubicin hydrochloride contribute to ADC therapeutic effects?
Daunorubicin hydrochloride exerts cytotoxic effects selectively in target cells when conjugated to antibodies. This targeted delivery reduces systemic toxicity while maintaining strong DNA-damaging activity to induce apoptosis in tumor cells.
12/5/2018
Dear BOC Sciences, which linkers are suitable for Daunorubicin hydrochloride conjugation?
Daunorubicin hydrochloride can be conjugated via cleavable linkers, including hydrazone or peptide-based linkers. These linkers ensure stable circulation and controlled intracellular release, optimizing ADC stability and efficacy.
8/8/2019
Is Daunorubicin hydrochloride applicable in preclinical ADC studies?
Yes, it is extensively used in preclinical ADC research to study cytotoxicity, pharmacokinetics, and antitumor efficacy. These studies inform ADC design and optimize therapeutic outcomes before clinical development.
25/9/2017
Dear BOC Sciences, what safety precautions should be followed for Daunorubicin hydrochloride?
Handling Daunorubicin hydrochloride requires strict laboratory safety, including PPE, fume hoods, and proper waste disposal, due to its potent DNA-damaging properties and potential systemic toxicity.
15/6/2019
— Dr. David Miller, Senior ADC Researcher (USA)
Daunorubicin hydrochloride from BOC Sciences exhibited outstanding purity, which was critical for our ADC conjugation studies.
8/8/2019
— Dr. John Miller, Principal Investigator (USA)
Daunorubicin hydrochloride from BOC Sciences maintained the highest level of purity across multiple deliveries.
15/6/2019
— Ms. Claudia Fischer, ADC Development Scientist (Germany)
The compound’s reproducibility in our ADC assays highlighted the reliability of BOC Sciences’ production.
25/9/2017
— Dr. Simon Turner, Research Manager (UK)
We were impressed with the comprehensive CoA and timely delivery of Daunorubicin hydrochloride.
16/2/2020
— Mr. Marco Bianchi, Biotech Specialist (Italy)
Daunorubicin hydrochloride performed exceptionally well in conjugation experiments, supporting our pipeline development.
— Dr. Isabelle Laurent, Medicinal Chemist (France)
Working with BOC Sciences for Daunorubicin hydrochloride sourcing has been seamless and professional.
12/5/2018
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