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MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH

  CAS No.: 1802520-40-6   Cat No.: BADC-01722 4.5  

MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH

Structure of 1802520-40-6

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ADC Linker
Molecular Formula
C28H36N6O10
Molecular Weight
616.62

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Synonyms
(R)-10-Benzyl-23-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-6,9,12,15,18-pentaoxo-3-oxa-5,8,11,14,17-pentaazatricosanoic acid
IUPAC Name
2-[[[2-[[(2R)-2-[[2-[[2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]methoxy]acetic acid
Canonical SMILES
C1=CC=C(C=C1)CC(C(=O)NCC(=O)NCOCC(=O)O)NC(=O)CNC(=O)CNC(=O)CCCCCN2C(=O)C=CC2=O
InChI
InChI=1S/C28H36N6O10/c35-21(9-5-2-6-12-34-25(39)10-11-26(34)40)29-14-22(36)30-16-24(38)33-20(13-19-7-3-1-4-8-19)28(43)31-15-23(37)32-18-44-17-27(41)42/h1,3-4,7-8,10-11,20H,2,5-6,9,12-18H2,(H,29,35)(H,30,36)(H,31,43)(H,32,37)(H,33,38)(H,41,42)/t20-/m1/s1
InChIKey
SODPQQOBNODMSG-HXUWFJFHSA-N

MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH, a synthetic peptide with vast potential in both research and therapeutic domains, offers a spectrum of applications.

Peptide Research: Delving into the realm of peptide structure and function, MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH serves as a valuable tool for researchers investigating protein interactions and the dynamic conformations of peptides. Its robust structure serves as a model system for unraveling the intricate folding patterns and molecular interactions of peptides, shedding light on their behavior in interaction with other biomolecules.

Drug Development: Positioned at the forefront of therapeutic innovation, this peptide emerges as a prime candidate in the development of novel drug entities. Its distinctive structure positions it as a promising candidate for targeting drug therapies, particularly in the domains of oncology and infectious diseases. Through strategic alterations to its chemical scaffold, scientists can engineer derivatives with heightened potency and specificity against diverse pathogenic targets, fostering advancements in therapeutic discovery.

Biomaterials Design: Embracing a pivotal role in biomaterial engineering, MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH can be seamlessly integrated into biomaterial matrices to bolster their physical and chemical attributes. By augmenting the stability and bioactivity of hydrogels, films, or coatings utilized in medical devices and tissue engineering scaffolds, this peptide facilitates the creation of advanced materials that nurture cell proliferation and tissue rejuvenation.

Biochemical Assays: As a cornerstone in designing biochemical assays for enzyme and receptor investigations, this peptide stands as a linchpin in high-throughput screening endeavors within biochemical and pharmaceutical research arenas. Its interactions with specific biomolecular partners pave the way for the creation of sophisticated assays aimed at identifying enzyme inhibitors or receptor activators with profound therapeutic implications, underscoring its pivotal role in driving drug discovery and development.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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