Lycorine HCl - CAS 2188-68-3

Lycorine HCl - CAS 2188-68-3 Catalog number: BADC-00290

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Lycorine is a toxic crystalline alkaloid found in various Amaryllidaceae species, such as the cultivated bush lily , surprise lilies, and daffodils. It may be highly poisonous, or even lethal, when ingested in certain quantities. Symptoms of lycorine toxicity are vomiting, diarrhea, and convulsions.

General Information

ADCs Cytotoxin
Product Name
Lycorine HCl
Catalog Number
Molecular Formula
Molecular Weight

Chemical Structure

  • Lycorine HCl

Ordering Information

Catalog Number Size Price Stock Quantity
BADC-00290 1 g $288 In stock
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98 %. (NMR)
Solid powder.
Lycorine chloride; Lycorine HCl; Lycorine (hydrochloride)
slightly in 95% alcohol; not well in water; not in chloroform.
Stable in dry state, store at + 4 °C, in dark place.
ADCs Cytotoxin
Room temperature
Melting Point
210-212 °C.
Canonical SMILES
InChI Key
1.Synergistic effects of the immune checkpoint inhibitor CTLA-4 combined with the growth inhibitor lycorine in a mouse model of renal cell carcinoma.
Li X;Xu P;Wang C;Xu N;Xu A;Xu Y;Sadahira T;Araki M;Wada K;Matsuura E;Watanabe M;Zheng J;Sun P;Huang P;Nasu Y;Liu C Oncotarget. 2017 Mar 28;8(13):21177-21186. doi: 10.18632/oncotarget.15505.
Renal cell carcinoma (RCC) management has undergone a major transformation over the past decade; immune checkpoint inhibitors are currently undergoing clinical trials and show promising results. However, the effectiveness of immune checkpoint inhibitors in patients with metastatic RCC (mRCC) is still limited. Lycorine, an alkaloid extracted from plants of the Amaryllidaceae family, is touted as a potential anti-cancer drug because of its demonstrative growth inhibition capacity (induction of cell cycle arrest and inhibition of vasculogenic mimicry formation). Moreover, T cell checkpoint blockade therapy with antibodies targeting cytotoxic T-lymphocyte associated protein 4 (CTLA-4) has improved outcomes in cancer patients. However, the anti-tumor efficacy of combined lycorine and anti-CTLA-4 therapy remains unknown. Thus, we investigated a combination therapy of lycorine hydrochloride and anti-CTLA-4 using a murine RCC model. As a means of in vitro confirmation, we found that lycorine hydrochloride inhibited the viability of various RCC cell lines. Furthermore, luciferase-expressing Renca cells were implanted in the left kidney and the lung of BALB/c mice to develop a RCC metastatic mouse model.

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