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INNO-206 (Aldoxorubicin) is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00027 | -- | $-- | Inquiry |
| NCT Number | Condition Or Disease | Phase | Start Date | Sponsor | Status |
|---|---|---|---|---|---|
| NCT01580397 | Pancreatic Ductal Adenocarcinoma | Phase 2 | 2013-06-28 | CytRx | Completed |
| NCT02014844 | Glioblastoma | Phase 2 | 2017-01-06 | CytRx | Completed |
| NCT01706835 | Advanced Solid Tumors | Phase 1 | 2014-12-17 | CytRx | Completed |
| NCT02235688 | Metastatic Solid Tumors | Phase 1 | 2017-06-07 | CytRx | Completed |
| NCT01337505 | Malignant Solid Tumour | Phase 1 | 2013-02-13 | CytRx | Completed |
INNO-206 is a novel prodrug of the potent cytotoxic agent monomethyl auristatin E (MMAE), designed for targeted cancer therapy. The compound is a part of the antibody-drug conjugate (ADC) strategy, where MMAE is conjugated to an antibody through a cleavable linker. INNO-206 uses the valine-citrulline (Vc) linker, which is specifically cleaved by enzymes inside cancer cells, allowing for the selective release of MMAE. This design enhances the specificity of drug delivery, reducing systemic toxicity and increasing the effectiveness of chemotherapy, making it a promising candidate for targeted cancer treatment.
The primary application of INNO-206 is in the treatment of various types of cancers, particularly those with overexpression of specific tumor-associated antigens. The ADC's antibody component is engineered to recognize and bind to these antigens, such as those found on the surface of cancer cells, enabling selective internalization and delivery of the potent MMAE payload. Once inside the cancer cell, the Vc linker is cleaved, releasing MMAE, which disrupts microtubule formation and induces cell death. This mechanism allows INNO-206 to target tumors while minimizing damage to healthy tissues, a major advantage in reducing the side effects commonly seen with conventional chemotherapy.
In addition to its use in cancer therapy, INNO-206 has potential applications in combination therapies. Researchers are exploring the combination of INNO-206 with immune checkpoint inhibitors or other immunotherapies to enhance the anti-tumor immune response. By selectively targeting and killing tumor cells, INNO-206 may promote the release of tumor antigens, stimulating the immune system to recognize and attack residual cancer cells. This approach is part of the growing field of immuno-oncology, where the combination of targeted therapies and immune system modulation holds the potential for more effective cancer treatments.
Another application of INNO-206 is in the development of precision medicine. The specificity of INNO-206 for tumor cells expressing the target antigen allows for a personalized treatment approach. By identifying biomarkers that predict which patients will benefit most from this targeted therapy, INNO-206 can be used to tailor treatment plans, ensuring that patients with specific tumor profiles receive the most appropriate and effective therapies. This strategy enhances the likelihood of treatment success and minimizes unnecessary exposure to toxic agents in patients who may not benefit from the drug.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, non-natural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
