H-L-Orn(N3)-OH hydrochloride is an azide-functionalized ornithine derivative ADC linker intermediate optimized for site-specific bioorthogonal conjugation and controlled drug release in antibody-drug conjugates. Keywords: ADC linker, azide linker, ornithine derivative, click chemistry, payload conjugation.
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H-L-Orn(N3)-OH hydrochloride is a chemical compound used extensively in the bioscience industry, particularly in research and medical applications. Here are some key applications of H-L-Orn(N3)-OH hydrochloride:
1. Peptide Synthesis: H-L-Orn(N3)-OH hydrochloride is often used as a building block in the synthesis of peptides. Its unique structure allows for the incorporation of azido groups, which are essential for click chemistry reactions. This facilitates the creation of complex peptides with high precision and specificity.
2. Drug Design and Development: In pharmaceutical research, H-L-Orn(N3)-OH hydrochloride is employed to develop novel therapeutic compounds. Its azido group can be modified to produce a variety of derivatives, enabling the exploration of new drug candidates. This versatility makes it a valuable tool in the discovery of drugs targeting specific diseases.
3. Bioconjugation Studies: H-L-Orn(N3)-OH hydrochloride is utilized in bioconjugation techniques to attach biomolecules to various surfaces or other biomolecules. The azido group can participate in click chemistry reactions, making it ideal for labeling proteins, nucleic acids, or other cellular components. This aids in the visualization and study of biological processes at a molecular level.
4. Protein Engineering: Researchers use H-L-Orn(N3)-OH hydrochloride in the field of protein engineering to introduce azido groups into proteins. These modified proteins can then undergo further chemical modifications, enabling the study of protein function and interactions. This approach is crucial for understanding the structure-function relationships of proteins and for developing protein-based therapeutics.
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