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FSP-2

  CAS No.:   Cat No.: BADC-00264   Purity: 99% (NMR). 4.5  

FSP-2 is a potent ADC cytotoxin designed for targeted cancer therapy, serving as an effective ADC payload. It induces DNA damage leading to tumor cell apoptosis, enhancing ADC efficacy in hematologic and solid tumors. Ideal for conjugation in next-gen antibody-drug conjugates, FSP-2 supports precision oncology applications.

FSP-2

Structure of

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Category
ADC Cytotoxin
Molecular Formula
C19H28F6NO5PS
Molecular Weight
527.46
Shipping
Room temperature
Shipping
store at room temperature.

* For research and manufacturing use only. We do not sell to patients.

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Capabilities & Facilities

Popular Publications Citing BOC Sciences Products
Solubility
Chloroform, acetone, ethanol and DMSO
Melting Point
75-77 °C.
Appearance
Solid powder
Shipping
Room temperature
Storage
store at room temperature.
NCT NumberCondition Or DiseasePhaseStart DateSponsorStatus
NCT03104088Cognitive Impairment2020-08-28University Hospital TuebingenCompleted
NCT03204773SPG42020-08-27University Hospital TuebingenCompleted
NCT03206190Hereditary Spastic ParaplegiaNot Applicable2021-09-29University Hospital TuebingenRecruiting
NCT04712812Hereditary Spastic Paraplegia2021-11-18Boston Children's HospitalRecruiting
1. Commutability of control materials for external quality assessment of serum apolipoprotein A-I measurement
Jun Dong, Weiyan Zhou, Ying Yan, Shu Wang, Jiangtao Zhang, Wenxiang Chen, Tianjiao Zhang, Jie Zeng, Chuanbao Zhang, Haijian Zhao, Rong Ma, Tianqi Qi Clin Chem Lab Med . 2018 Apr 25;56(5):789-795. doi: 10.1515/cclm-2017-0652.
Background:The aim of the current study was to evaluate the commutability of commercial control materials and human serum pools and to investigate the suitability of the materials for the external quality assessment (EQA) of serum apolipoprotein A-I (apo A-I) measurement.Methods:The Clinical and Laboratory Standards Institute (CLSI) EP14-A3 protocol was used for the commutability study. Apo A-I concentrations in two levels of commercial control materials used in EQA program, two fresh-frozen human serum pools (FSPs) and two frozen human serum pools prepared from residual clinical specimens (RSPs) were measured along with 50 individual samples using nine commercial assays. Measurement results of the 50 individual samples obtained with different assays were pairwise analyzed by Deming regression, and 95% prediction intervals (PIs) were calculated. The commutability of the processed materials was evaluated by comparing the measurement results of the materials with the limits of the PIs.Results:The FSP-1 was commutable for all the 36 assay pairs, and FSP-2 was commutable for 30 pairs; RSP-1 and RSP-2 showed commutability for 27/36 and 22/36 assay pairs, respectively, whereas the two EQA materials were commutable only for 4/36 and 5/36 assay pairs, respectively.Conclusions:Non-commutability of the tested EQA materials has been observed among current apo A-I assays. EQA programs need either to take into account the commutability-related biases in the interpretation of the EQA results or to use more commutable materials. Frozen human serum pools were commutable for most of the assays.
2. Ascus development in two temperature-sensitive four-spore mutants of Neurospora crassa
N B Raju Can J Genet Cytol . 1986 Dec;28(6):982-90. doi: 10.1139/g86-136.
Two nonallelic Four-spore mutants are known in which ascospore walls enclose the four immediate products of meiosis rather than the normal eight products of a postmeiotic mitosis. Expression depends on temperature. The Four-spore phenotype is expressed when the developing asci are subjected either to high temperatures (25-30 degrees C) for Fsp-1 or to low temperatures (15-20 degrees C) for Fsp-2. Heterozygous Fsp-1 X Fsp-1+ crosses make eight-spored asci at 15-20 degrees C but produce many four-spored asci at 25 degrees C and mostly four-spored asci at 30 degrees C. Homozygous Fsp-1 X Fsp-1 crosses respond similarly to increasing temperature but make 40-50% four-spored asci even at 20 degrees C. Heterozygous Fsp-2 X Fsp-2+ crosses produce almost exclusively four-spored asci at 15 degrees C but a mixture of four- and eight-spored asci at 20, 25, and 30 degrees C. Homozygous Fsp-2 X Fsp-2 crosses make all four-spored asci at 15 and 20 degrees C and a mixture of four- and eight-spored asci at 25 and 30 degrees C. When both Fsp-1 and Fsp-2 are present in a cross, either homozygous or heterozygous, no asci contain more than four ascospores at any temperature. Limited temperature-shift experiments with Fsp-1 and Fsp-2 show that the sensitive period for Four-spore expression is sometime after meiotic prophase, possibly at interphase II.
3. N-(3-[18F]fluoropropyl)-spiperone: the preferred 18F labeled spiperone analog for positron emission tomographic studies of the dopamine receptor
J A Katzenellenbogen, D Y Chi, M J Welch, K E Carlson, M R Kilbourn, M E Raichle, C J Mathias, J S Perlmutter, C S Dence, J W Brodack Int J Rad Appl Instrum B . 1988;15(1):83-97. doi: 10.1016/0883-2897(88)90164-x.
The ligands currently used for PET studies of the dopamine receptor are fluorine-18-labeled spiperone (FSp) and carbon-11 or fluorine-18-labeled N-methyl-spiperone. All three of these ligands have drawbacks in either their chemical preparation or their biological behavior. We have previously prepared a series of N-fluoroalkyl-spiperone derivatives which are simple to prepare in high radiochemical yield. N-[18F]fluoropropyl-spiperone (3-F-Pr-Sp) and N-[18F]fluoroethyl-spiperone (2-F-Et-Sp) were the most promising ligands. In vitro competitive binding studies showed affinities for the dopamine receptor of 3-F-Pr-Sp greater than FSp greater than 2-F-Et-Sp. Brain extraction studies in a primate model showed that FSp, 2-F-Et-Sp, and 3-F-Pr-Sp were not completely extracted by the brain. High bone uptake and kidney clearance was observed with 3-F-Pr-Sp, while 2-F-Et-Sp cleared through the intestine in rats. This is in contrast to FSp where clearance is through the kidney. Studies to evaluate the extraction of metabolites in the brain were carried out by administering large doses (10 mCi) of FSp, 2-F-Et-Sp and 3-F-Pr-Sp to rats and reinjecting the metabolites in blood into other rats. These experiments showed that less than 0.02% of the metabolites from FSp and 3-F-Pr-Sp entered the brain, while 0.5% of the metabolites from 2-F-Et-Sp entered the brain. The majority of the activity present in the cerebellum after the administration of 2-F-Et-Sp is metabolites; therefore 2-F-Et-Sp is unsuitable for PET imaging studies. PET imaging studies in baboons and in one normal human volunteer with 3-F-Pr-Sp showed a high striatum-to-cerebellum ratio, showing that 3-F-Pr-Sp can replace ligands currently in use to study dopamine receptors.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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