Name: DBCO-SS-aldehyde
Brand: BOC Sciences
Rating: 5 (1 reviews)

IUPAC Name

Canonical SMILES

C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCNC(=O)CCSSCCNC(=O)C4=CC=C(C=C4)C=O

InChI

InChI=1S/C31H29N3O4S2/c35-22-23-9-11-26(12-10-23)31(38)33-18-20-40-39-19-16-29(36)32-17-15-30(37)34-21-27-7-2-1-5-24(27)13-14-25-6-3-4-8-28(25)34/h1-12,22H,15-21H2,(H,32,36)(H,33,38)

InChIKey

RQSKTIYFMRQDRL-UHFFFAOYSA-N

Solubility

10 mm in DMSO

Appearance

white foam

Shelf Life

≥ 2 years

Shipping

Room temperature

Storage

Store at -20 °C, keep in dry and avoid sunlight.

DBCO-SS-aldehyde, a versatile chemical linker utilized in bioconjugation, plays a pivotal role in binding molecules to proteins, peptides, or other biomolecules. Here are four key applications of DBCO-SS-aldehyde:

Antibody-Drug Conjugates: Integral to the synthesis of antibody-drug conjugates (ADCs), DBCO-SS-aldehyde enables the coupling of a drug molecule to an antibody. This strategic linking allows ADCs to selectively target and deliver cytotoxic agents specifically to cancer cells, minimizing harm to healthy cells and enhancing the efficacy of cancer therapy.

Protein Labeling: An essential component in protein labeling, DBCO-SS-aldehyde serves as a crucial tool for attaching fluorescent dyes, biotin, or other detection tags to proteins. This process enables precise visualization, tracking, and quantification of proteins in diverse biological studies, facilitating in-depth exploration of protein interactions, localization, and functions within living cells.

Click Chemistry: Widely employed in “click” chemistry reactions, DBCO-SS-aldehyde stands out for its efficient and selective conjugation capabilities. Its compatibility with azide-functionalized molecules allows for rapid and specific bioconjugation, simplifying the synthesis of intricate biomolecular structures and propelling advancements in drug discovery and molecular diagnostics.

Functional Biomaterials: Leveraging DBCO-SS-aldehyde, researchers can modify and enhance biomaterials for various applications, including tissue engineering and regenerative medicine. By attaching bioactive molecules to scaffold materials, they can boost cell attachment, proliferation, and differentiation, leading to the creation of sophisticated biomaterials that closely mimic natural tissue environments.