Name: DBCO-SS-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

IUPAC Name

Canonical SMILES

C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCC(=O)NCCSSCCN

InChI

InChI=1S/C23H25N3O2S2/c24-13-15-29-30-16-14-25-22(27)11-12-23(28)26-17-20-7-2-1-5-18(20)9-10-19-6-3-4-8-21(19)26/h1-8H,11-17,24H2,(H,25,27)

InChIKey

CZMYTLNFEACBDG-UHFFFAOYSA-N

Solubility

10 mm in DMSO

Appearance

white foam

Shelf Life

0-4°C for short term (days to weeks), or -20°C for long term (months).

Shipping

Room temperature

Storage

Store at -20 °C, keep in dry and avoid sunlight.

DBCO-SS-amine, a versatile bifunctional reagent renowned for its ability to forge enduring linkages, finds multifaceted applications in bio-conjugation and various biochemical endeavors. Here are four key applications of DBCO-SS-amine:

Protein Labeling: Employing DBCO-SS-amine, researchers adorn proteins with diverse probes like fluorescent dyes or biotin, leveraging the strain-promoted azide-alkyne cycloaddition (SPAAC) reaction for bioorthogonal labeling that seamlessly integrates with biological processes. This practice is pivotal for delving into protein localization, interactions, and dynamics within living cells, offering invaluable insights into cellular mechanisms.

Drug Delivery Systems: DBCO-SS-amine plays a pivotal role in crafting targeted drug delivery systems by tethering therapeutic molecules to precise targeting ligands, enhancing treatment specificity and efficacy by directing drugs to specific cells or tissues. This precision in drug delivery not only minimizes side effects but also amplifies therapeutic outcomes.

Surface Functionalization: In the realm of surface modification, DBCO-SS-amine emerges as a potent tool for immobilizing biomolecules on diverse substrates, such as beads, microarrays, and biosensors, enabling the creation of sophisticated diagnostic platforms and biomaterials. By introducing functional groups on these surfaces, DBCO-SS-amine catalyzes the development of cutting-edge tools for capturing specific analytes, thereby heightening sensitivity and specificity in analytical assays.

Antibody-Drug Conjugates (ADCs): Integral to the synthesis of ADCs, DBCO-SS-amine plays a pivotal role in channeling cytotoxic drugs specifically to cancer cells, leveraging its bifunctional nature to securely affix the drug to antibodies for targeted delivery, sparing normal tissues while selectively attacking tumor cells. ADCs represent a promising frontier in cancer therapy, merging the precision of antibodies with the potency of small-molecule drugs, heralding a paradigm shift in oncological treatment strategies.