Azido-PEG3-Val-Cit-PAB-OH - CAS 2055024-65-0

Azido-PEG3-Val-Cit-PAB-OH - CAS 2055024-65-0 Catalog number: BADC-01039

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Category
ADCs Linker
Product Name
Azido-PEG3-Val-Cit-PAB-OH
CAS
2055024-65-0
Catalog Number
BADC-01039
Molecular Formula
C27H44N8O8
Molecular Weight
608.69
Azido-PEG3-Val-Cit-PAB-OH

Ordering Information

Catalog Number Size Price Quantity
BADC-01039 -- $--
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Synonyms
(S)-2-((S)-1-azido-14-isopropyl-12-oxo-3,6,9-trioxa-13-azapentadecan-15-amido)-N-(4-(hydroxymethyl)phenyl)-5-ureidopentanamide
Canonical SMILES
CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)CO)NC(=O)CCOCCOCCOCCN=[N+]=[N-]
InChI
InChI=1S/C27H44N8O8/c1-19(2)24(34-23(37)9-12-41-14-16-43-17-15-42-13-11-31-35-29)26(39)33-22(4-3-10-30-27(28)40)25(38)32-21-7-5-20(18-36)6-8-21/h5-8,19,22,24,36H,3-4,9-18H2,1-2H3,(H,32,38)(H,33,39)(H,34,37)(H3,28,30,40)/t22-,24-/m0/s1
InChIKey
UNBTYONTPDVRKD-UPVQGACJSA-N
Solubility
10 mm in DMSO
Appearance
Solid
Purity
>98.0%
Shelf Life
-20°C 3 years powder; -80°C 2 years in solvent
Shipping
-20°C (International: -20°C)
Storage
-20°C
Form
Solid

Azido-PEG3-Val-Cit-PAB-OH, a versatile linker molecule extensively utilized in the biosciences, offers a myriad of applications in drug delivery and bioconjugation. Here are four key applications presented with a high degree of perplexity and burstiness:

Antibody-Drug Conjugates (ADCs): Serving as a pivotal component in the synthesis of antibody-drug conjugates, Azido-PEG3-Val-Cit-PAB-OH acts as a cleavable linker that intricately connects the antibody and cytotoxic drug. This intricate design ensures the precise release of the drug within target cells upon internalization, enhancing the specificity and potency of cancer therapies. By minimizing off-target effects and maximizing therapeutic outcomes, this innovative approach revolutionizes the landscape of cancer treatment.

Prodrug Development: Embracing the concept of prodrug development, this versatile linker molecule plays a pivotal role in connecting the active drug molecule to a carrier, thereby enhancing solubility and stability. Upon reaching the desired target site, the linker undergoes cleavage, releasing the active drug and facilitating optimal drug delivery and bioavailability. This strategic approach transforms the field of drug development, fostering more efficacious treatments across various medical conditions.

Targeted Drug Delivery: Taking the lead in targeted drug delivery systems, Azido-PEG3-Val-Cit-PAB-OH contributes to the creation of nanoparticles and liposomes by attaching targeting ligands. This innovative approach enhances the precision of therapeutic delivery to specific cells or tissues, such as tumor sites or inflammatory regions, while simultaneously reducing systemic side effects. By optimizing the delivery mechanism, this cutting-edge technology elevates treatment efficacy and patient outcomes.

Bioconjugation: The presence of the azido group within Azido-PEG3-Val-Cit-PAB-OH facilitates click chemistry-based bioconjugation, a crucial process for attaching biomolecules to surfaces, drug carriers, or other macromolecules. This streamlined approach enables the development of multifunctional biomaterials and advanced diagnostic tools, propelling bioscience research forward. The efficiency and simplicity of bioconjugation techniques streamline experimental procedures, ushering in a new wave of innovative applications in the realm of biochemistry and molecular biology.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Azido-PEG3-Val-Cit-PAB-OH
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