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| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01039 | -- | $-- | Inquiry |
Azido-PEG3-Val-Cit-PAB-OH, a versatile linker molecule extensively utilized in the biosciences, offers a myriad of applications in drug delivery and bioconjugation. Here are four key applications presented with a high degree of perplexity and burstiness:
Antibody-Drug Conjugates (ADCs): Serving as a pivotal component in the synthesis of antibody-drug conjugates, Azido-PEG3-Val-Cit-PAB-OH acts as a cleavable linker that intricately connects the antibody and cytotoxic drug. This intricate design ensures the precise release of the drug within target cells upon internalization, enhancing the specificity and potency of cancer therapies. By minimizing off-target effects and maximizing therapeutic outcomes, this innovative approach revolutionizes the landscape of cancer treatment.
Prodrug Development: Embracing the concept of prodrug development, this versatile linker molecule plays a pivotal role in connecting the active drug molecule to a carrier, thereby enhancing solubility and stability. Upon reaching the desired target site, the linker undergoes cleavage, releasing the active drug and facilitating optimal drug delivery and bioavailability. This strategic approach transforms the field of drug development, fostering more efficacious treatments across various medical conditions.
Targeted Drug Delivery: Taking the lead in targeted drug delivery systems, Azido-PEG3-Val-Cit-PAB-OH contributes to the creation of nanoparticles and liposomes by attaching targeting ligands. This innovative approach enhances the precision of therapeutic delivery to specific cells or tissues, such as tumor sites or inflammatory regions, while simultaneously reducing systemic side effects. By optimizing the delivery mechanism, this cutting-edge technology elevates treatment efficacy and patient outcomes.
Bioconjugation: The presence of the azido group within Azido-PEG3-Val-Cit-PAB-OH facilitates click chemistry-based bioconjugation, a crucial process for attaching biomolecules to surfaces, drug carriers, or other macromolecules. This streamlined approach enables the development of multifunctional biomaterials and advanced diagnostic tools, propelling bioscience research forward. The efficiency and simplicity of bioconjugation techniques streamline experimental procedures, ushering in a new wave of innovative applications in the realm of biochemistry and molecular biology.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
