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N-(4-Carboxycyclohexylmethyl)maleimide is a PROTAC linker, which is composed of alkyl chains. N-(4-Carboxycyclohexylmethyl)maleimide can be used to synthesize a range of PROTACs.
![N-[4-(-Carboxycyclohexylmethyl)]maleimide](https://resource.bocsci.com/structure/64987-82-2.gif)
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01622 | -- | $-- | Inquiry |
N-[4-(Carboxycyclohexylmethyl)]maleimide is a versatile compound extensively utilized in bioconjugation, particularly in the development of antibody-drug conjugates (ADCs). Its maleimide functional group reacts selectively with thiol groups, enabling the formation of stable thioether linkages. This specificity is critical in creating ADCs with precise drug-to-antibody ratios, improving therapeutic efficacy and minimizing off-target effects. In addition, the compound's stability under physiological conditions ensures that the conjugate remains intact until it reaches the target site, further enhancing its value in pharmaceutical applications.
Another significant application of N-[4-(Carboxycyclohexylmethyl)]maleimide is in protein labeling and modification. The carboxylic acid group allows for the introduction of hydrophilic characteristics, making the compound suitable for aqueous environments. This property is particularly beneficial in designing protein-based diagnostics and therapeutics, as it minimizes aggregation and ensures solubility. The selective reactivity of the maleimide group also enables the precise modification of proteins, facilitating the study of their structure and function in various biological systems.
The compound also finds utility in polymer chemistry, where it serves as a crosslinking agent. Its dual functional groups, carboxyl and maleimide, enable the formation of complex polymer networks with tailored properties. Such polymers are employed in drug delivery systems, where they offer controlled release capabilities and enhanced biocompatibility. Additionally, these polymers are integral in tissue engineering, providing scaffolds that mimic natural extracellular matrices for cell growth and differentiation.
In addition to its roles in pharmaceuticals and polymer science, N-[4-(Carboxycyclohexylmethyl)]maleimide is widely used in the development of biosensors. Its ability to conjugate with biomolecules makes it ideal for immobilizing enzymes, antibodies, or other biological entities on sensor surfaces. This application enhances the sensitivity and specificity of biosensors, making them valuable tools in medical diagnostics, environmental monitoring, and food safety analysis.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
